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Biodegradable materials, preparation method and usage

A biodegradable material and weight technology, applied in the field of biomedical polymer materials, can solve problems such as poor solubility and rheology, unstable aqueous solution, and difficult storage, and achieve stable performance, easy mastery, and simple process.

Inactive Publication Date: 2006-04-19
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural konjac glucomannan has a large molecular weight, poor solubility and rheological properties, and the aqueous solution is not stable and easy to degrade, and it is not easy to store, so its application is limited.

Method used

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  • Biodegradable materials, preparation method and usage
  • Biodegradable materials, preparation method and usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 1 g of konjac glucomannan and dissolve it in 200 ml of distilled water, stir at room temperature for 1 to 6 hours to form a uniform sol. Polyacrylic acid was made into 200 ml aqueous solution of 0.5% by weight. Mix 200 ml of konjac glucomannan sol, 200 ml of polyacrylic acid solution, and 0.1 g of plasticizer at room temperature for 1 to 6 hours to make a transparent glue. The transparent glue solution is stable and has good atomization property, and can be used as a film coating solution for drug cores.

Embodiment 2

[0023] Weigh 0.5 g of konjac glucomannan and dissolve it in 200 ml of distilled water, stir at room temperature for 1 to 6 hours to form a uniform sol. Polyacrylic acid was made into 200 ml aqueous solution of 0.75% by weight. Mix 200 ml of konjac glucomannan sol, 200 ml of polyacrylic acid solution, and 0.1 g of plasticizer at room temperature for 1 to 6 hours to make a transparent glue. Add chemical fertilizers and pesticides to the transparent glue, stir evenly, dry, crush or granulate slow-release products with an extrusion granulator. Or the drug sustained-release preparation is prepared by coating the core comprising the active pharmaceutical ingredient and the pharmaceutically acceptable excipient with a film coating solution.

Embodiment 3

[0025] Weigh 1.5 g of konjac glucomannan and dissolve it in 300 ml of distilled water, stir at room temperature for 1 to 6 hours to form a uniform sol. Polyacrylic acid is made into 100 ml aqueous solution of 0.5% by weight. Mix 300 ml of konjac glucomannan sol, 100 ml of polyacrylic acid solution, and 0.1 g of plasticizer at room temperature for 1 to 6 hours to make a transparent glue and make a seed coating agent to keep the seeds fresh. Mix 100 g of Legume seeds or grain seeds are mixed with it and air-dried at room temperature.

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Abstract

A biodegradable material used as slow-releasing material or release-controllable material is prepared from konjak glucomannan (1-85 Wt%), polyacrylic acid (1-85) and plasticizer (0-15) through mixing. Its advantages are not dissolving in water, high stability and mechanical performance, and high biodegradability.

Description

technical field [0001] The invention relates to a preparation method and application of a blended biodegradable material. The film does not use any crosslinking agent, has a certain degree of swelling but does not dissolve in an aqueous solution, and belongs to the field of biomedical polymer materials. Background technique [0002] Controlled release is a technology that combines active substances and substrates (usually polymer materials) to release active substances into the environment at a certain rate within a certain period of time through diffusion. It is used in medicine, biology, agriculture, Environmental protection and daily life are of great significance, and more and more people are paying more and more attention. Substrates have always been a research hotspot in controlled release technology, and people have been looking for substrates with simple preparation, stable performance, low price and abundant sources. [0003] Konjac is one of the main crops in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/02C08L33/02C08K5/05C08J5/18
Inventor 肖超渤余慧群黄义宏鲁俊
Owner WUHAN UNIV
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