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Medicine composition for preparing hepatic diseases and its use thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as poor formulation stability and controllability

Inactive Publication Date: 2006-05-31
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the common traditional Chinese medicine preparations for the treatment of liver fibrosis and early liver cirrhosis are mostly compound preparations. Chinese medicine compound prescriptions are the characteristics of traditional Chinese medicine and an important basis for clinical efficacy, and have comprehensive pharmacological effects. During the research process, the stability and controllability of the preparation are relatively poor, so reducing the drug composition as much as possible is the current trend in the treatment of liver fibrosis and cirrhosis. The present invention is formed on this basis, and the active ingredients in the drug are as clear as possible , the curative effect is confirmed, the quality is controllable, and it is more in line with the requirements of modern drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Embodiment 1: the preparation method of salvia miltiorrhiza extract

[0092] Take red ginseng and extract with water twice, the first time is 2 hours, 6 times the amount of water; the second time is 1 hour, 4 times the amount of water; the extract is concentrated under reduced pressure to a density of 1.05-1.10 (60 degrees), alcohol precipitation 50% , stand overnight; filter, ethanol precipitate supernatant, concentrate under reduced pressure until no alcohol smell, apply macroporous resin (crude drug: resin = 1:1); wash with water, 3 to 6 times the amount; 50% ethanol elution 3 to 4 times the amount; the eluate is concentrated under reduced pressure and dried to make the Danshen extract.

Embodiment 2

[0093] Embodiment 2: the preparation method of salvia miltiorrhiza extract

[0094] (a) removing impurities from Salvia miltiorrhiza, cutting into small pieces or pulverizing into coarse powder, extracting with hot water, adjusting the pH of the extract to acidity, and filtering;

[0095] (b) Put the filtrate on a polyamide column, wash with water until the pH value is neutral, then elute with a weak alkaline aqueous solution, and collect the alkali eluent;

[0096] (c) After adjusting the pH value of the alkali eluent to acidity, put it on a macroporous adsorption resin column, wash it with water until the pH value is neutral, then elute with water or anhydrous lower alcohol, and collect the eluate;

[0097] (d) Concentrate the eluent under reduced pressure until it is free of alcohol, and dry to obtain the Danshen extract.

[0098] Wherein: in step (a), heat and extract with water for 2 to 4 times, each time for 0.5 hours to 2 hours, the temperature of extraction is 6 (0 to...

Embodiment 3

[0101] Embodiment 3: the preparation method of Panax notoginseng extract

[0102] Take Panax notoginseng fine powder and add 13 times the weight of the medicinal materials, the concentration is 30% ethanol extraction solvent, the extraction temperature is 70 ° C, the heating time is 40 minutes, heat and reflux with ethanol to extract twice, filter, combine the filtrates, and recover under reduced pressure Ethanol to a certain amount, add an appropriate amount of water, continue to recover until there is no alcohol smell, add water so that every 2ml of the liquid medicine is equivalent to 1g of crude drug, the liquid medicine is passed through the pretreated macroporous adsorption resin, washed with water until the effluent is colorless, and replaced with 55 % ethanol elution, check the elution end point with TCL, add 1.1% activated carbon (according to the feeding amount) to the eluent, reflux for decolorization for 30min, filter while it is hot, cool, the filtrate passes throu...

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Abstract

A Chinese medicine for treating hepatofibrosis and heptocirrhosis is prepared from red sage root and notogenseng.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for preparing liver diseases and its application. Background technique [0002] Hepatitis is a common and frequently-occurring disease. my country is a high-incidence area for viral hepatitis. If these patients cannot be effectively treated, liver fibrosis may occur, and then liver cirrhosis. The "trilogy" composed of "hepatitis, liver fibrosis, and cirrhosis" is a common path for various chronic liver diseases to lead to serious consequences. Since liver cirrhosis is a substantial lesion of the liver, it is generally believed that it is difficult to reverse, so in addition to symptomatic treatment, other effective measures are lacking. And for the treatment of viral hepatitis, although there are a few medicines with certain curative effect at present, the cure rate is unsatisfactory, and the expense is expensive. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P1/16
Inventor 叶正良张文生
Owner TIANJIN TASLY PHARMA CO LTD
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