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Dindoly methylane and preparation process thereof

A technology of diindolylmethane and indolylmethane, which is applied in the field of indole derivatives, can solve the problems of expensive, cumbersome, and polluting catalyst preparations, and achieve the effects of low cost, low pollution, and great development advantages

Inactive Publication Date: 2006-06-28
OCEAN UNIV OF CHINA
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  • Claims
  • Application Information

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Problems solved by technology

And these methods all use formaldehyde or other aldehydes or ketones as raw materials, and the disadvantages are that the preparation of the catalyst used is cumbersome and expensive, so it is necessary to develop a new preparation method to reduce production costs, simplify production steps, and eliminate environmental pollution. Pollution

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  • Dindoly methylane and preparation process thereof
  • Dindoly methylane and preparation process thereof
  • Dindoly methylane and preparation process thereof

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Experimental program
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Embodiment Construction

[0011] Add 5.9g (0.05mol) of indole, 7.6g (0.075mol) of N-methylolacrylamide, 150mL of ethanol and 5mL of glacial acetic acid in a 250mL single-necked bottle in sequence, and then place it in a water bath at 50°C for 7 days with electromagnetic stirring and sealed reaction . Remove most of the ethanol solvent by rotary evaporation, pour the concentrated solution into a beaker, and let it stand still. White crystals precipitate in the beaker, filter with suction, wash the solid with a small amount of chloroform for 3 times, and dry it with an electric vacuum dryer to obtain a white flake 5.3 g of crystals, yield 85.4%, melting point 168.5°C, the product is DIM.

[0012] If the indole in the above reaction is replaced by 5-bromo-1-hydroindole or 5,6-dichloro-1-hydroindole, 3,3'-di(5-bromoindol)yl methane can be obtained respectively (BBIM) and 3,3'-bis(5,6-dichloroindol) methane (BCIM); if the glacial acetic acid in the above reaction is replaced by sulfuric acid, zinc chloride...

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Abstract

The invention relates to 2-indyl methane. The feature is that molecular formula is C17H10N2X2Y2, of which X is H, Br, Cl; Y is H, Br, Cl. It uses indole or indole ramification and N-methylol acrylamide as raw material and, uses alcohol as solvent, under the catalyst of acid, takes reaction to form 2-indyl methane. The mol ratio of the reacting material is 1:0.2-2; reacting temperature is 10-80 degree centigrade; reaction time is 6-240 hours. The invention decreases cost, lowers pollution, and has high yield.

Description

technical field [0001] The invention relates to an indole derivative, in particular to a diindolylmethane compound and a preparation method thereof. Background technique [0002] Because of its unique chemical structure, indole and its derivatives make medicines and pesticides have unique physiological activities, and have attracted worldwide attention. 3,3-Diindolylmethane (DIM) widely exists in natural products and has a series of biological activities. Studies by Wattenberg and Loub have shown that: DIM present in cruciferous vegetables (such as cabbage, cauliflower, Brussels sprouts, cauliflower, etc.) has the effect of blocking DMBA-induced mammary gland tumors in rats, and adding it to feed In this method, the animals eating the feed will not grow the forestomach tumor induced by benzopyrene, and have no toxic and side effects. Therefore, it can be widely used as a component of a new generation of anticancer agents. Traditional diindolylmethane is synthesized from i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/04
Inventor 于良民李昌诚姜晓辉张志明徐焕志王利
Owner OCEAN UNIV OF CHINA