Organic germanium injection and preparation process thereof

A technology of organic germanium and injections, applied in antiviral agents, pharmaceutical formulas, drug combinations, etc., can solve the problems of vulnerable parts of the action, restrictions on the promotion and application of organic germanium, and the absorption rate cannot reach a good blood concentration. Achieve the effect that the preparation process is simple and feasible

Inactive Publication Date: 2006-07-26
潘维新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no injection preparation containing organic germanium. It is generally an oral preparation. When used, due to reasons such as absorption rate, it cannot reach a good blood concentration, and the action site is also easily affected, so it is not easy to exert its anti-tumor and anti-tumor effects. The role of AIDS virus limits the popularization and application of organic germanium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation prescription (1000ml capacity):

[0031] Organic germanium 0.1g, water for injection was added to 1000ml.

[0032] The preparation process is as follows:

[0033] Add organic germanium to 900ml water for injection according to the prescription, mix, heat to 100°C, stir to make it fully dissolved; filter with 0.22μm membrane, adjust pH to 7.5, add water for injection to 1000ml, potting, 120°C, Sterilized in 20 minutes, packaged, and made into intravenous fluid.

Embodiment 2

[0035] Preparation prescription (1000ml capacity):

[0036] Organic germanium 0.1g, Grifola frondosa polysaccharide 0.02g, water for injection was added to 1000ml.

[0037] The preparation process is as follows:

[0038] According to the prescription, add organic germanium and Grifola frondosa polysaccharide into 950ml water for injection, mix, heat to 100°C, stir to make it fully dissolved; add an appropriate amount of activated carbon, stir and absorb for 20 minutes, decarbonize, filter with 0.22μm membrane, adjust pH 7.8, add water for injection to make up to 1000ml, potting, sterilizing at 120°C for 20 minutes, packaging, and making intramuscular injection.

Embodiment 3

[0040] Preparation prescription (1000ml capacity):

[0041] Organic germanium 0.1g, Ganoderma lucidum polysaccharide 0.05g, water for injection was added to 1000ml.

[0042] The preparation process is as follows:

[0043] According to the prescription, add organic germanium and Ganoderma lucidum polysaccharide into 950ml water for injection, mix, heat to 100°C, stir to make it fully dissolved; add an appropriate amount of activated carbon, stir and absorb for 20 minutes, decarbonize, filter through a 0.22μm membrane, and adjust the pH to 7.8 , add water for injection to make up to 1000ml, potting, sterilizing at 120°C for 20 minutes, packaging, and making intravenous injection.

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PUM

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Abstract

The invention relates to an organic germanium injection and its preparing process, wherein the injection is prepared from organic germanium, compound of organic germanium, polysaccharides and organic germanium polysaccharide through mixing with water for injection, heating, stirring for complete dissolving, filtering, adjusting pH, keeping constant volume, encapsulating, sterilizing and packaging.

Description

technical field [0001] The invention relates to a preparation of organic germanium, in particular to an injection of organic germanium, and also relates to a preparation process of the preparation. Background technique [0002] Organic germanium (Ge-132) is an important active ingredient of famous traditional Chinese medicines such as ginseng and ganoderma lucidum, and its molecular formula is (CH 2 CH 2 COOH Ge) 2 o 3 , is a white powder, odorless, insoluble in ethanol and ether, soluble in alkali and water. [0003] Studies have shown that cancer cells have a higher potential than normal cells and are prone to division and proliferation. Ge-132 can capture hydrogen ions from cancer cells, thereby reducing cell potential, changing their physiological state, until inhibiting their reproduction, and preventing it from spreading to other parts. According to another study, Ge-132 has a certain inhibitory effect on HIV reverse transcriptase. [0004] At present, there is no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/08A61P35/00A61P31/18
Inventor 潘维新
Owner 潘维新
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