Supercritical CO2 extraction process of total rhubarb anthraquinone

A carbon dioxide and supercritical technology, applied in the direction of hydrocarbon production from carbon oxides, organic chemistry, quinone separation/purification, etc., can solve the problems that there is no supercritical carbon dioxide extraction of total anthraquinone extract of rhubarb, and avoid high temperature hydrolysis , less pollution and shorter extraction time

Inactive Publication Date: 2006-08-02
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the literature search, so far there is no report of using supercritical carbon dioxide to extract the total anthraquinone extract of rhubarb

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 1.5 kg of rhubarb medicinal material powder, spray and infiltrate with 300 ml of 50% ethanol, and after airtight and stuffy for 0.5 hours, put it into a 5 L specification supercritical extraction device extraction kettle, use supercritical carbon dioxide as the extraction solvent, and the extraction process is carried out at a pressure of 20Mpa, temperature is 30 ℃, the time is to carry out in the environment of 0.5 hour, in the whole extraction process, with the 300ml concentration of 5 milliliters / minute flow rate, be that the ethanol of 60% extracts as entrainer and solvent; Under reduced pressure analysis and separation at ℃, collect about 550ml of ethanol solution of rhubarb total anthraquinones, concentrate and dry under reduced pressure to obtain 30.0 g of its extract, the sample yield is 2.00%, and the content of total anthraquinones in the sample is 32.5%.

Embodiment 2

[0023] Weigh 1.5 kg of rhubarb medicinal material powder, spray and infiltrate with 300 ml of 95% ethanol, and after airtight and stuffy for 3 hours, put it into a 5 L specification supercritical extraction device extraction kettle, use supercritical carbon dioxide as the extraction solvent, and the extraction process is carried out at a pressure of 35Mpa, temperature is 50 ℃, the time is to carry out in the environment of 2 hours, in the whole extraction process, with the concentration of 3 milliliters / min of 500ml flow rate, be that the ethanol of 95% extracts as entrainer and solvent; Under reduced pressure analysis and separation at 25°C, about 800ml of ethanol solution of rhubarb total anthraquinones was collected, concentrated and dried under reduced pressure to obtain 32.1g of its extract, the sample yield was 2.14%, and the total anthraquinone content in the sample was 36.4%.

Embodiment 3

[0025] Weigh 1.5kg of rhubarb medicinal material and grind it into fine powder, spray it with 300ml of absolute ethanol for infiltration, seal it for 1 hour, put it into a 5L supercritical extraction device extraction kettle, and use supercritical carbon dioxide as the extraction solvent. Pressure is 30Mpa, temperature is 40 ℃, the time is carried out in the environment of 3 hours, in the whole extraction process, with the concentration of 2 milliliters / minute with 750ml flow velocity, be that the ethanol of 90% extracts as entrainer and solvent; Under reduced pressure analysis and separation at a temperature of 30°C, about 1000ml of the ethanol solution of rhubarb total anthraquinones was collected, concentrated and dried under reduced pressure to obtain 38.0g of its extract, the sample yield was 2.53%, and the content of total anthraquinones in the sample was 31.5% %.

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Abstract

The present invention belongs to the field of effective Chinese medicine component extracting technology, and is especially supercritical CO2 extraction process of total rhubarb anthraquinone. Rhubarb powder through or through no acid solution treatment is soaked in alcohol or other solvent and extracted in a extracting reactor with supercritical CO2 as extractant and alcohol as entrainer and solvent at pressure of 20-60 Mpa and temperature of 30-60 deg.c for 0.5-3 hr. The extracted matter is decompression separated in a separating tank at 15-45 deg.c, and alcohol solution of total rhubarb anthraquinone is collected and decompression concentrated and dried to obtain total rhubarb anthraquinone.

Description

technical field [0001] The invention belongs to the technical field of extraction of effective components in traditional Chinese medicine, and in particular relates to the technical field of extracting total anthraquinones of effective components in rhubarb by supercritical carbon dioxide technology. Background technique [0002] Rhubarb is the dry root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. or medicinal Rheum officinale Baill. of Polygonaceae. Rhubarb relieves heat and clears the intestines, cools the blood and detoxifies, expels blood stasis and stimulates the menstrual flow. [0003] Rhubarb is one of the four most commonly used traditional Chinese medicines, and more than 800 of the more than 8,000 traditional Chinese medicine preparations in the country contain rhubarb. Rhubarb has a purging effect, and has been used as a purgative since ancient times to treat dry stools and heat-constipated constipation. Most Chinese patent medicines and hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C46/10C07C50/18C07C66/02C07C1/08
CPCY02P20/54
Inventor 肖小河孙玉琦马永刚曹俊岭邢小燕
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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