Levalbuterol slow-release tablet and its preparing method
A technology of levosalbutamol and sustained-release tablets, which is applied in pharmaceutical formulations, drug delivery, and respiratory diseases. drug stability, prolonged effect
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Embodiment 1
[0029] After levosalbutamol 5g, lactose 60g, and hydroxypropyl methylcellulose 10g are passed through 80 meshes, mix them uniformly to obtain a mixture; dissolve hydroxypropylmethylcellulose 5g in 100ml ethanol as a binding agent; add the binding agent to In the mixture, the soft material is made, and then the whole grain is made. Dry in an oven at 55°C; granulate with a 16-mesh sieve; the granulated dry granules are evenly mixed with 5 g of magnesium stearate, used as the final blended material, and pressed into tablets to obtain plain tablets. Dissolve 10 g of ethyl cellulose and 5 g of hydroxypropyl methyl cellulose in 200 ml of ethanol, and suspend them evenly. The plain tablet is coated. After coating, carry out aluminum-plastic packaging, and leave the factory after passing the inspection.
Embodiment 2
[0031] Levosalbutamol 1g, microcrystalline cellulose MCC 50g, and hydroxypropyl methylcellulose 20g were passed through 80 meshes, and mixed uniformly to obtain a mixture; Povidone K30 10g was dissolved in 100ml ethanol as a binder; the binder Add it to the mixture to make soft material, and then make granules. Dry in an oven at 50°C; granulate with a 16-mesh sieve; the granulated dry granules are evenly mixed with 1 g of magnesium stearate as the final blended material, and pressed into tablets to obtain plain tablets. Dissolve 17g of acrylic resin and 1g of hydroxypropylmethylcellulose in 200ml of ethanol, and suspend them evenly. The plain tablet is coated. After coating, carry out aluminum-plastic packaging, and leave the factory after passing the inspection.
Embodiment 3
[0033] After levosalbutamol 3g, lactose 70g, MCC 10g, pass through 80 meshes, mix evenly to obtain a mixture; dissolve 8g of hydroxypropylmethylcellulose in 100ml ethanol as a binder; add the binder to the mixture to prepare Soft material, then whole grain. Dry in an oven at 50°C; granulate with a 16-mesh sieve; the granulated dry granules are evenly mixed with 3 g of magnesium stearate, used as the final blended material, and pressed into tablets to obtain plain tablets. Dissolve 5 g of ethyl cellulose and 1 g of hydroxypropyl methyl cellulose in 200 ml of ethanol, and suspend them evenly. The plain tablet is coated. After coating, carry out aluminum-plastic packaging, and leave the factory after passing the inspection.
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