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Method for preparing total flavone extract of many prickle acanthopanax

A technology of Acanthopanax leaves and total flavonoids, which is applied in the field of preparation of Acanthopanax leaves total flavonoids extract, and can solve the problems of poor selectivity and low content of total flavonoids

Inactive Publication Date: 2006-08-09
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And macroporous adsorption resin is because the selectivity to flavonoids is relatively poor, the total flavonoid content of the extract that obtains is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] 5kg of Acanthopanax senticosus leaves are removed, broken, placed in an extraction tank, added 40% ethanol to reflux and extracted 4 times, each time for 1 hour, each time adding ethanol volume L: the weight of Acanthopanax senticosus leaves in Kg is 6: 1. The extracts were combined, concentrated, filtered, added to the treated polyamide column, eluted with water until the effluent was nearly colorless, then eluted with 10% ethanol until the effluent was light yellow, and discarded the eluate liquid, and then eluted with 40% ethanol, collected the eluate until the effluent was light yellow, recovered the ethanol and concentrated it, and spray-dried to obtain the total flavonoids extract of Acanthopanax senticosus leaves of the present invention.

Embodiment 2

[0009] 5kg of Acanthopanax senticosus leaves are removed and broken, placed in an extraction tank, added 50% ethanol to reflux and extracted twice, each time for 3 hours, adding ethanol volume L each time: the weight of Acanthopanax senticosus leaves in Kg is 11: 1. The extracts were combined, concentrated, filtered, added to the treated polyamide column, eluted with water until the effluent was nearly colorless, then eluted with 20% ethanol until the effluent was light yellow, and discarded the eluate liquid, and then eluted with 50% ethanol, collected the eluent until the effluent was light yellow, recovered the ethanol and concentrated it, and spray-dried to obtain the total flavonoids extract of Acanthopanax senticosus leaves of the present invention.

Embodiment 3

[0011] 5kg of Acanthopanax senticosus leaves are removed and broken, placed in an extraction tank, added 60% ethanol to reflux and extracted twice, each time for 2.5 hours, adding ethanol volume L each time: the weight of Acanthopanax senticosus leaves in Kg is 12: 1. The extracts were combined, concentrated, filtered, added to the treated polyamide column, eluted with water until the effluent was nearly colorless, then eluted with 30% ethanol until the effluent was light yellow, and discarded the eluate liquid, then eluted with 60% ethanol, collected the eluate until the effluent was light yellow, recovered the ethanol and concentrated it, and spray-dried to obtain the total flavonoids extract of Acanthopanax senticosus leaves of the present invention.

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Abstract

The present invention relates to a manyprickle acanthopanax leaf total flavone extract preparation method. Said preparation method includes the following steps: using manyprickle acanthopanax leaf as raw material, removing impurity, cutting, adding ethyl alcohol to make reflux extraction in extraction tank for 2-4 times, every time is 1-3 hr, combining extracts, concentrating, filtering, adding the filtrate into polyamide column, using water to make elution, then using ethyl alcohol to make elution, recovering ethyl alcohol, concentrating and spray-drying so as to obtain the manyprickle acanthopanax leaf total flavone extract whose total flavone content is 50%-99%.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to a preparation method of total flavonoids extract from Acanthopanax senticosus leaves. Background technique [0002] The extraction method of various preparations using Acanthopanax senticosus as raw material is generally water extraction and alcohol precipitation extraction method. Compared with alcohol extraction method, the extraction rate of flavonoids is lower in the water extraction method of this method. Song Shiyue et al. [Chinese patent, 11133176] used Acanthopanax as raw material for Acanthopanax injection powder and used water extraction and alcohol precipitation extraction to obtain the Acanthopanax extract through a macroporous resin column separation method. However, due to the poor selectivity of the macroporous adsorption resin to flavonoids, the total flavonoid content of the obtained extract is not high. Contents of the invention [0003] The purpose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61P25/00
Inventor 刘志强宋凤瑞刘淑莹
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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