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Vaccine composition for treating B-type hepatitis and preparing method

A technology of hepatitis B vaccine and composition, applied in the directions of drug combination, pharmaceutical formula, antibody medical ingredients, etc.

Inactive Publication Date: 2006-08-09
广州市恺泰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are recombinant yeast hepatitis B vaccine (HBsAg), T cell epitope lipopolypeptide therapeutic vaccine and DNA plasmid vaccine being developed in China. All three vaccines are under clinical observation and have not yet entered the market.

Method used

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Embodiment

[0025] The recombinant yeast hepatitis B vaccine (HBsAg) in the embodiment of the present invention is a gift from Dalian Hanxin Biological Products Co., Ltd., the recombinant human IL-12 is developed by the applicant itself, and IL-2 can be obtained from Shenzhen Kexing Biological Engineering Co., Ltd. The recombinant human IL-12, after years of experimental research, has established a CHO cell line with high expression and stable IL-12. This cell line is characterized by increasing the expression intensity of p35 subunits to make p35 and p40 two The expression of each subunit is balanced, because only the expression of p35 and p40 can increase the expression of IL-12 with biological activity. After cell culture and protein purification, the pure IL-12 has been obtained. Protein purification is to centrifuge the cell culture solution to remove cells and debris, and purify the centrifuged supernatant. The IL-12 monoclonal antibody was connected to activated Sepharose to prepare an...

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PUM

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Abstract

This invention discloses a new style curing hepatitis B combination and its preparation method; it belongs to biological agent field. The vaccine pharmaceutics carries recombination yeast hepatitis B and human recombination IL-l2, their weight ratio is 60-80:2-10. the preparation method is that recombination yeast hepatitis B and L-l2, or recombination yeast hepatitis B and IL-l2 and IL-2 are directly mixed to make hepatitis B vaccine combination, pharmaceutics is water agent. This invention has better therapeutic effect, and is used for hepatitis B curing.

Description

Technical field [0001] The present invention relates to a biological preparation, in particular to a novel therapeutic hepatitis B vaccine composition for hepatitis B treatment, and the invention also relates to a preparation method of the vaccine composition. Background technique [0002] Chronic hepatitis B is a common and frequently-occurring disease in my country. The prevalence rates of HBV markers and hepatitis B surface antigen (HBsAg) in the general population in my country are 57.6% and 9.7%, respectively. It is estimated that about 700 million people have been infected with HBV, of which 120 million are chronic carriers of HBsAg, and about 300,000 die each year due to chronic hepatitis B. example. However, the treatment of chronic hepatitis B has not yet made breakthrough progress. [0003] At present, the main treatment of chronic hepatitis B is the use of antiviral and immunomodulatory agents. Antiviral drugs are α-interferon and nucleoside analogs lamivudine and adef...

Claims

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Application Information

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IPC IPC(8): A61K39/29A61P31/20A61P1/16
Inventor 王添章夏书奇杨联勇张宜俊邱向南
Owner 广州市恺泰生物科技有限公司
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