New houttuynine sodium bisulfite injection and its preparation method and use

A new houttuyfonate sodium and injection technology, which is applied in the field of chemical medicine, can solve the problems of inconvenient clinical use, deterioration of medicinal solution, refusal to use, etc.

Inactive Publication Date: 2006-09-13
诺氏制药(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it brings inconvenience to clinical use, and even doctors and patients may mistakenly think that the liquid medicine has deteriorated and refuse to use it.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Firstly, thoroughly grind neohouttuydin sodium with 10 times the amount of Tween-80 to obtain the drug solution A, and then take water for injection 1 times the amount of the drug solution A, add 0.05% sodium bisulfite and stir well to completely dissolve, To obtain liquid medicine B; fully mix liquid medicine A and liquid medicine B evenly, add 0.03% activated carbon, heat and boil for 30 minutes, decarbonize and filter, and finally adjust the pH value to 4.5, fill, sterilize, and light Inspection, packaging into injection.

Embodiment 2

[0030] First, fully grind the new houttuyfonate sodium and 20 times the amount of Tween-80 to obtain the drug solution A, and then take water for injection 3 times the amount of the drug solution A, add 0.08% sodium bisulfite and stir well to completely dissolve, To obtain liquid medicine B; fully mix liquid medicine A and liquid medicine B evenly, add 0.1% activated carbon, heat and boil for 20 minutes, decarbonize and filter, and finally adjust the pH value to 5.0, fill, sterilize, and light Inspection, packaging into injection.

Embodiment 3

[0032] First, thoroughly grind the new houttuyfonate sodium and 1 times the amount of Tween-80 to obtain the drug solution A, and then take 5 times the amount of water for injection of the drug solution A, add 1.0% sodium bisulfite and stir well to completely dissolve, To obtain liquid medicine B; fully mix liquid medicine A and liquid medicine B evenly, add 0.4% activated carbon, heat and boil for 20 minutes, decarbonize and filter, and finally adjust the pH value to 6.0, fill, sterilize, and light Inspection, packaging into injection.

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PUM

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Abstract

A sodium neohouttuyfonate injection for treating adnexitis, pelvic inflammation, chronic cervicitis, upper respiratory tract infection, chronic bronchitis, pneumonia, etc is prepared from sodium neohouttuyfonate, tween-80 sodium hydrogen sulfite and the water for injection. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a novel houttuyfonate sodium injection and its preparation method and application, belonging to the field of chemical medicine. Background technique [0002] The main ingredient of New Houttuyfonate Sodium Injection is New Houttuyfonate Sodium, the chemical name is sodium bisulfite adduct of laurylacetaldehyde, it is white scaly or needle-like crystal or crystalline powder, with slight odor . Soluble in hot water, slightly soluble in water and ethanol, almost insoluble in chloroform and benzene, soluble in sodium hydroxide test, but decomposed at the same time. The melting point is 162-166°C, and it decomposes while melting. [0003] This product is a chemical synthesis of an aldehyde component in the volatile oil of the whole herb of Tribaumaceae. It has obvious inhibitory effect on pneumococcus, typhoid bacillus, staphylococcus aureus, Escherichia coli and sporothrix. It can improve the body's immunity, enhance the phagoc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K9/08A61P11/00
Inventor 郭智华
Owner 诺氏制药(吉林)有限公司
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