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Compositions for the preparation of carbon dioxide gel for external use and carbon dioxide gels for external use

A carbon dioxide and composition technology, which is applied in the directions of drug combinations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of inconvenient use, not convenient to use, soiling clothes, etc.

Inactive Publication Date: 2006-09-20
NEOCHEMIR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, since bubble-like carbon dioxide will form useless cavities in the composition obtained from the kit, the carbon dioxide will not be used for transdermal and transmucosal absorption
At the same time, there is a problem that the overall fluidity becomes high, and the application material drips from the application surface and stains clothes, etc.
Furthermore, the composition obtained by the aforementioned kit is viscous, so when removed after use, it is necessary to wash the face, which is inconvenient to use
[0007] On the other hand, although the composition of WO02 / 80941 almost solves the disadvantages of the kit of JP-A-2000-319187, it also needs to be washed after use, and it is not convenient to use.
In addition, even if stronger cosmetic or medical effects can be obtained in a shorter period of time than the aforementioned kits, further improvements in effects are expected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] (Preparation of Granular Matter (A))

[0095] Using 57 parts of sodium dihydrogen phosphate as a weak acid and 43 parts of disodium ethylenediaminetetraacetate as a calcium ion scavenger, a granular granular material (average particle diameter: 0.3 mm) was prepared with an appropriate amount of water.

[0096] (Modulation of sticky (B))

[0097] Using 1 part of calcium carbonate, 3.5 parts of sodium alginate as a gelling agent gelled by calcium ions, 87.9 parts of purified water as water, and carboxymethyl as an adhesive to improve the affinity with the skin and mucous membrane surface Prepare sticky substance (B ).

[0098] Then, the obtained granular material (A) and the viscous material (B) were combined to prepare a carbon dioxide external gel preparation composition.

Embodiment 2

[0100] (Preparation of Granular Matter (A))

[0101] Use 53 parts of sodium dihydrogen phosphate as a weak acid, 6 parts of disodium edetate as a calcium ion scavenger, 36 parts of lactose as a dispersant, and 5 parts of dextrin as a binder, and prepare with an appropriate amount of water Granular granular matter (average particle size: 0.2mm).

[0102] (Modulation of sticky (B))

[0103] Using 0.4 parts of calcium carbonate, 3.5 parts of sodium alginate as a gelling agent gelled by calcium ions, 86 parts of purified water as water, and carboxymethyl as an adhesive to improve the affinity with the surface of the skin and mucous membranes Prepare sticky substance (B ).

[0104] Then, the obtained granular material (A) and the viscous material (B) were combined to prepare a carbon dioxide external gel preparation composition.

Embodiment 3

[0106] (Preparation of Granular Matter (A))

[0107] Use 56 parts of sodium dihydrogen phosphate as a weak acid, 6 parts of disodium edetate as a calcium ion scavenger, 33 parts of lactose as a dispersant, and 5 parts of dextrin as a binder, and prepare with an appropriate amount of water Granular granular matter (average particle size: 0.3mm).

[0108] (Modulation of sticky (B))

[0109]Using 0.3 parts of calcium carbonate, 3.5 parts of sodium alginate as a gelling agent gelled by calcium ions, 85.1 parts of purified water as water, and carboxymethyl as an adhesive to improve affinity with the surface of the skin and mucous membranes Prepare sticky substance (B ).

[0110] Then, the obtained granular material (A) and the viscous material (B) were combined to prepare a carbon dioxide external gel preparation composition.

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PUM

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Abstract

The compositions for the preparation of carbon dioxide gels for external use are to be used in the preparation of a carbon dioxide gel for external use consisting of a gel and carbon dioxide dissolved therein in a substantially non-bubble state and are each composed of granules and a viscous substance to be mixed with the granules. In the first composition for the preparation of carbon dioxide gel, the granules comprise a weak acid and a calcium ion scavenger as the essential components, and the viscous substance comprises calcium carbonate, a gelling agent causing gelation with calcium ions, and water as the essential components. In the second composition, the granules comprise a weak acid and a dispersant as the essential components, and the viscous substance comprises calcium carbonate, a gelling agent causing gelation with calcium ions, a calcium ion scavenger, and water as the essential components.

Description

technical field [0001] The present invention relates to a carbon dioxide external gel preparation composition for preparing a carbon dioxide external gel that can easily obtain cosmetic or medical effects by external use of carbon dioxide, and a carbon dioxide external gel obtained therefrom. Background technique [0002] Carbon dioxide absorbed percutaneously and through mucous membranes activates metabolism by promoting blood circulation in the skin, subcutaneous tissue, and muscles, thereby obtaining cosmetic or medical effects. Carbonated springs and various Confirmed by various research institutes. For example, as an application to the treatment of bedsores in medical effects, Hiyoshi et al. reported that artificial carbonated springs are effective for refractory bedsores (Hiyoshi Toshiki; About the treatment of bedsores with artificial carbonated spring baths. Comprehensive Rehabilitation 17 (8): 605- 609, 1989). [0003] In order to easily obtain cosmetic or medical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/02A61Q19/00A61K9/06A61K47/02A61K47/18A61K47/36A61K33/10A61K8/04A61K33/00
CPCA61K33/00A61K47/18A61Q19/00A61K47/02A61K9/0014A61K8/0275A61K33/10A61K2800/222A61K47/36A61P17/00A61P17/02
Inventor 田中雅也魏春红
Owner NEOCHEMIR INC