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Method for fermentation preparation of 7-amino-3-deacetoxy cephalosporanic acid

A technology for acetoxy cephalosporanic acid and a production method, which is applied in the field of straight-through production of 7-amino-3-deacetoxy cephalosporanic acid fermentation, can solve the problem of large amount of acid and ammonia water, large amount of waste water discharge, and high product yield. problems such as low rate, to achieve the effect of high product quality, improved yield, protection of operating environment and social environment

Inactive Publication Date: 2006-10-04
周新基
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Problems solved by technology

[0002] The existing production method of 7-amino-3-desacetoxycephalosporanic acid comprises penicillin oxidation, ring expansion, ammonia dissolution, hydrolysis, decolorization, cooling, crystallization, suction filtration, cyclohexanoic acid dissolution through ammonia water, cracking, Decolorization, crystallization, suction filtration and other steps, the process flow is long, the operation is complicated, the waste water discharge is large, the acid and ammonia water consumption is large, the product yield is low (not exceeding 40%), and the content of the final product is low (not exceeding 97%)

Method used

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Embodiment Construction

[0016] A fermentation straight-through production method of 7-amino-3-desacetoxycephalosporanic acid (i.e. 7-ADCA), is characterized in that: comprises the following steps successively:

[0017] (1) penicillin fermentation, ring expansion: add penicillin 150~250 parts by weight (example 150 parts by weight, 200 parts by weight, 250 parts by weight), 8000~12000 parts by weight (examples 8000, 10000, 12000 parts by weight) parts by weight) of sterile water, 1 to 3 parts by weight (example 1, 2, 3 parts by weight) of THIX-298 high-efficiency pharmaceutical fermentation defoamer (produced by Nantong Sutong Chemical Fertilizer Co., Ltd.), and add ST03-X II fermentation Enzyme (produced by Nantong Sutong Chemical Fertilizer Co., Ltd.) 30~50 parts by weight (example 30,40,50 parts by weight) is fermented, nutrient solution is dripped with 2~3 parts by weight per hour in 8~12 hours before fermentation, after 6~ The same nutrient solution was added dropwise at 1 to 2 parts by weight pe...

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Abstract

The disclosed fermentation method for 7-amido-3-deacetoxylcephalosporanic acid comprises: adding penicillin, water, defoamer, fermenting enzyme and nutrient solution into the kettle; after fermentation, extracting the water phase with CHCl3 then reverse extracting the organic phase with water, dewatering, cracking, crystallizing, and suction filtering to obtain the product. This invention increases yield / product content up to 42.5% / 98.5%, and reduces cost and pollution.

Description

Technical field: [0001] The invention relates to a production method of 7-amino-3-desacetoxycephalosporanic acid. Background technique: [0002] The existing production method of 7-amino-3-desacetoxy cephalosporanic acid includes penicillin oxidation, ring expansion, ammonia dissolution, hydrolysis, decolorization, cooling, crystallization, suction filtration, cyclohexanoic acid dissolution through ammonia water, cracking, Decolorization, crystallization, suction filtration and other steps, the process flow is long, the operation is complicated, the waste water discharge is large, the acid and ammonia water consumption is large, the product yield is low (not exceeding 40%), and the content of the final product is low (not exceeding 97%) . Invention content: [0003] The purpose of the present invention is to provide a kind of step is simple, and product yield is high, the production method of 7-amino-3-desacetoxy cephalosporanic acid with good product quality. [0004] T...

Claims

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Application Information

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IPC IPC(8): C12P35/00
Inventor 周新基郭金煌赵可贵邓潭李文建
Owner 周新基
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