Hemostatic notoginseng chewing tablet and preparation method thereof
A technology of chewable tablets and notoginseng, which is applied in the field of notoginseng hemostatic chewable tablets and its preparation, can solve the problems of low bioavailability, difficulty in long-term use by patients, bitter taste, etc., and achieve improved stability, bioavailability and Good efficacy and taste
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Embodiment 1
[0050] Clean the notoginseng medicinal material, dry it, put it in an ultrafine pulverizer, and sieve it through a 200-mesh sieve to obtain a fine powder of notoginseng for later use;
[0051] Take 15g of gelatin, add 900ml of water, heat and stir to dissolve the gelatin completely, then add 25g of the extract of Dianthus chinensis, stir to make the dispersion even; then add 10g of mannitol, 4g of lactose and 0.6g of aspartame, and stir until completely dissolved ; Keep the temperature at 40-60°C, dry it into fine powder by spray drying method, and obtain the wrapper of Dijincao extract;
[0052] Add 6.2g Panax notoginseng fine powder, 4g lactose, 10g mannitol, 1.8g PVP-K30, 0.2g aspartame, 0.2g coffee essence to the obtained Dijincao extract wrapping, mix well, and use an appropriate amount of 95% ethanol The solution is granulated, dried at 60°C, granulated, then mixed with 0.4g magnesium stearate; compressed into 100 tablets, and then wrapped with a waterproof film coat.
Embodiment 2
[0054] Clean the notoginseng medicinal material, dry it, put it in an ultrafine pulverizer, and sieve it through a 200-mesh sieve to obtain a fine powder of notoginseng for later use;
[0055] Take 25g of gelatin, add 900ml of water, heat and stir to dissolve the gelatin completely, then add 20g of the extract of Dianthus chinensis, stir to make the dispersion even; then add 10g of mannitol, 4g of lactose and 0.6g of aspartame, and keep the temperature at 40 Stir at ~60°C until completely dissolved; dry it into a fine powder by freeze-drying method to obtain the capsule of Dijincao extract;
[0056]Add 8g Panax notoginseng fine powder, 4g lactose, 5g microcrystalline cellulose, 1.8g PVP-K30, 0.2g aspartame, 0.2g cream essence to the package of Dijincao extract; mix well with 95% ethanol The solution is granulated, dried at 60°C, granulated, then mixed with 0.4g magnesium stearate; compressed into 100 tablets, and then wrapped with a waterproof film coat.
Embodiment 3
[0058] Clean the notoginseng medicinal material, dry it, put it in an ultrafine pulverizer, and sieve it through a 200-mesh sieve to obtain a fine powder of notoginseng for later use;
[0059] Take 30g of PEG6000, add 900ml of water, heat and stir to completely dissolve PEG6000, then add 25g of Dijincao extract, stir to make the dispersion even; then add 5g of mannitol, 0.6g of aspartame, and stir until completely dissolved; keep the temperature at Dry at 40-60°C by vacuum drying method, and then pulverize into fine powder to obtain solid dispersion of Dijincao extract;
[0060] Add 10g Panax notoginseng fine powder, 5g mannitol, 5g lactose, 5g microcrystalline cellulose, 1.8g PVP-K30, 0.2g aspartame, 0.3g butter essence to the solid dispersion of Dijincao extract and mix well; Granulate with an appropriate amount of 95% ethanol solution, dry at 60°C, granulate, then add 0.4g of magnesium stearate and mix well; press into 100 tablets, and then wrap with a waterproof film coat....
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