Unlock instant, AI-driven research and patent intelligence for your innovation.

Lincomycin hydrochloride composition and its prepn

A technology of lincomycin hydrochloride and composition, which is applied in the field of ophthalmic lincomycin hydrochloride composition, can solve the problems of poor reducibility, inconvenient use and the like, and achieves the effects of long residence time, convenient use and good curative effect

Active Publication Date: 2007-01-03
SHANGHAI SINE PHARMA LAB
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor reducibility of this type of gel, it is also inconvenient to use, because it must be used and stored at low temperature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lincomycin hydrochloride composition and its prepn
  • Lincomycin hydrochloride composition and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Lincomycin hydrochloride composition formula:

[0069] Lincomycin hydrochloride 0.25g (Changzhou Lanling Pharmaceutical Co., Ltd.)

[0070] Sodium hyaluronate 0.2g (Shanghai Huayuan Life Science Research and Development Co., Ltd.)

[0071] Anhydrous sodium dihydrogen phosphate 0.17g (Jiangsu Taicang Chemical Plant No. 2)

[0072] Anhydrous disodium hydrogen phosphate 0.83g (Zhejiang Huzhou Chemical Reagent Factory)

[0073] Sodium chloride 0.5g (Nantong Qinfen Pharmaceutical Factory)

[0074] Ethylparaben 0.03g (Shanghai Wulian Chemical Factory)

[0075] Appropriate amount of hydrochloric acid or sodium hydroxide: adjust the pH to 6.0

[0076] Water for injection: add to 100ml

[0077] The preparation method of above-mentioned composition is as follows:

[0078] Weigh the prescribed amount of buffer component phosphate, add a full amount of 3 / 5 (v / v) of water for injection to prepare a buffer solution. Add the lincomycin hydrochloride raw material of prescription...

Embodiment 2

[0084] Lincomycin hydrochloride composition formula:

[0085] Lincomycin hydrochloride 0.25g (Changzhou Lanling Pharmaceutical Co., Ltd.)

[0086] Sodium hyaluronate 0.2g (Shanghai Huayuan Life Science Research and Development Co., Ltd.)

[0087] Boric acid 1.2g (Shanghai Yunling Chemical Factory)

[0088] Borax 0.056g (Sichuan Zigong Honghe Chemical Factory)

[0089] Sodium chloride 0.22g

[0090] Potassium chloride 0.067g (Shanghai Zhenxin Reagent Factory)

[0091] Benzalkonium chloride 0.01g (Shanghai Jingwei Chemical Co., Ltd.)

[0092] Appropriate amount of hydrochloric acid or sodium hydroxide: adjust the pH to 7.0

[0093] Water for injection: add to 100ml

[0094] The preparation method is as described in Example 1, except that the buffer components used are boric acid and borax, and the antiseptic component used is benzalkonium chloride.

Embodiment 3

[0096] Lincomycin Hydrochloride 0.25g

[0097] Sodium Hyaluronate 0.2g

[0098] Sodium dihydrogen phosphate (anhydrous) 0.17g

[0099] Disodium hydrogen phosphate (anhydrous) 0.83g

[0100] Sodium chloride 0.5g

[0101] Ethylparaben 0.03g

[0102] Appropriate amount of hydrochloric acid or sodium hydroxide: adjust the pH to 6.5

[0103] Water for injection: 100ml

[0104] The preparation method is as follows:

[0105] 1. Weigh the prescribed amount of sodium dihydrogen phosphate and disodium hydrogen phosphate, and add 3 / 5 (v / v) of water for injection to make a buffer solution. Add the lincomycin hydrochloride raw material of prescription amount wherein, stir to make it dissolve completely.

[0106] 2. Add sodium hyaluronate to the prepared water for injection of 1 / 4 (v / v) of the full amount, heat to 50°C, and stir to dissolve.

[0107] 3. Add the sodium hyaluronate solution to the above buffer solution, then add the prescribed amount of sodium chloride, and stir conti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides one kind of lincomycin hydrochloride composition comprising lincomycin hydrochloride 0.05-1 wt%, sodium hyaluronate 0.01-0.5 wt%, isoosmotic regulator 0.1-2.5 wt% and pharmaceutically acceptable carrier for the rest. The present invention also provides the preparation process of the lincomycin hydrochloride composition, and the preparation process includes the following steps: preparing solution A of lincomycin hydrochloride through adding lincomycin hydrochloride in 0.05-1 weight portion into buffering boric acid or phosphoric acid solution in 40-80 weight portions; preparing solution B of sodium hyaluronate through adding sodium hyaluronate in 0.01-0.5 weight portions into water in 15-35 weight portions, heating to 40-60 deg.c and stirring to dissolve; and mixing solution A and solution B to obtain the lincomycin hydrochloride composition.

Description

technical field [0001] The invention relates to an ophthalmic lincomycin hydrochloride composition with antibacterial and anti-inflammatory effects and a preparation method thereof. Background technique [0002] Lincomycin hydrochloride has a good effect on Gram-positive cocci. It is a semi-synthetic antibiotic developed in the 1960s. (Lincoln) City soil, an antibiotic produced by Streptomyces isolated from the culture solution, synthesized in 1966, and domestically produced in 1975. It has been included in Chinese Pharmacopoeia, Australian, British, French, German, Italian, Japanese, New Zealand, Portuguese, Swiss and American Pharmacopoeias. This product is a narrow-spectrum antibiotic, its effect is similar to that of erythromycin, and it is highly effective against anaerobic bacteria, Staphylococcus aureus and pneumococcus. Its mechanism of action is similar to that of erythromycin, and it is a bacteriostatic agent. Mainly inhibits bacterial cell protein synthesis. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61P27/02
Inventor 朱正鸣乌旭琼张冬梅夏凌云陈佩丽
Owner SHANGHAI SINE PHARMA LAB
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com