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Compositions and methods for improved occlusion of vascular defects

A blockage, blood vessel technology, applied in the direction of drug combination, blood disease, tissue regeneration, etc., can solve problems such as increased blood clot formation or stroke, difficult to control coils, etc.

Inactive Publication Date: 2007-01-10
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, intravascular coils also have significant drawbacks
These coils are difficult to control during insertion, and they can tangle or protrude into the bloodstream, increasing the likelihood of clot formation or stroke
What's more, the coil can only fill 30% of an aneurysm's volume

Method used

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  • Compositions and methods for improved occlusion of vascular defects
  • Compositions and methods for improved occlusion of vascular defects
  • Compositions and methods for improved occlusion of vascular defects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1 - Alginate biocompatibility

[0108]Short- and long-term tissue reactivity was tested by injecting calcium alginate in the fat capsule around the kidneys of 32 300±50 g rats. The rats were anesthetized with a ketamine cocktail (50 mg ketamine, 5 mg xylazine, 1 mg PromAce) at a dose of 0.5-1 ml per animal. A 3 cm incision is made on the left side of the abdomen. The fat capsule surrounding the left kidney was isolated. Make a bag in the kidney side capsule and inject about 0.5ml of alginate and 0.68M CaCl at a volume ratio of 2 2H 2 O and polymerize. Each of the four polymers was injected into the kidneys of two rats to examine the significance of the tissue response over time (total of 8 rats over time). The other kidney of each rat was left untreated as a control. Eight rats in each group were sacrificed after 1 day, 1 week, 3 weeks and 9 weeks, and the whole experiment was 32 rats. Two kidneys from each rat were harvested. Tissue reactivity was first...

Embodiment 2

[0113] Embodiment 2-alginate molecular weight characteristic

[0114] The apparent viscosity (unit mPas) and molecular weight (MW, g / mol) of alginate are often used to indicate the length of the alginate molecular chain that reacts. The apparent viscosity of unreacted alginate was determined by producing a 1.0 wt % solution of alginate in water and measuring its viscosity at 20°C. The apparent viscosity is directly proportional to the molecular weight of alginate. Molecular weights can be determined by size exclusion chromatography and multi-angle laser light scattering detection analysis. Purified high G-content alginate (PHG) has different molecular weights, which affects the workable concentration and final viscosity of alginate in solution state. The mechanical stability and polymer yield of various PHG alginates were tested in vitro based on the final viscosity:

[0115] ·PHG alginate, apparent viscosity 34mPas, molecular weight 78000g / mol, G / M 68 / 32

[0116] ·PHG alg...

Embodiment 3

[0122] Example 3 - In Vitro Aneurysm Model

[0123] Studies of ALGEL occlusions were performed using an in vitro aneurysm model made from a glass tube that was then cast into a model of elastic polymer resin. The vessel model simulates accurate vessel size and aneurysm size formation on the carotid artery (C), midbrain (MC) branch, and forebrain (AC) branch ( image 3 ). The model allows testing of endovascular embolization treatments in a simulated surgical setting. The resulting blockage can be subjected to pulsatile blood flow and pressure for up to two weeks. After embolization, the ALGEL samples were removed from the model for further analysis of the effectiveness and mechanical stability of the plug.

[0124] The model consists of a pulsatile pump that simulates systolic-diastolic blood flow and pressure effects (200ml / min, 160-80mmHg). Artificial blood was used to accurately model viscosity, ionic composition, and protein composition. Artificial blood was prepared ...

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Abstract

The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.

Description

technical field [0001] The present invention generally relates to compositions and methods for forming intravascular occlusions for the treatment of conditions such as aneurysms, arteriovenous malformations, tumor hyperinfusion, massive vascular bleeding, and other conditions requiring embolization for relief. More specifically, the present invention relates to compositions and methods using calcium alginate, without or without an intravascular coil or similar device, to form an occlusion at a targeted location of the occlusion in a mammalian body. Background technique [0002] Neurovascular injuries and brain tumors threaten the lives of thousands of people worldwide. Aneurysms, arteriovenous malformations ("AVMs"), and brain tumors affect patients of all ages and races. The frequency of lesion growth was evenly distributed among all races. [0003] Aneurysms often form over time from genetic defects in the development of blood vessel elasticity. The normal pressure even...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61L31/04A61L24/04A61L24/08A61B17/12
CPCA61L31/042A61B17/12186A61B17/12022A61B17/12109A61B17/12118A61B17/12136A61B17/1215A61B17/1219A61L2430/36A61P35/00A61P7/04C08L5/04
Inventor T·A·贝克D·R·柯克C·G·麦克道尔
Owner RGT UNIV OF MICHIGAN
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