Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

An injection used in vascular anastomosis or intravascular occlusion

An injection and anastomosis technology, applied in the field of medical supplies, can solve the problems of not obtaining national approval and high synthesis cost, and achieve good biocompatibility and convenient vascular anastomosis

Active Publication Date: 2018-08-07
YANTAI YENEPHARMA BIOMEDICAL +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic invention patent (application number CN102989036A) discloses a hydrogel for vascular anastomosis containing heparin-poloxamer. This invention synthesizes heparin-poloxamer through an esterification reaction to form a gel at 37.5-45 degrees Celsius, but As a polymer material for intravascular injection, heparin-poloxamer has not obtained any national approval, nor has it undergone any preclinical or clinical safety evaluation, and the synthesis cost is high
It can be seen that the above three technologies cannot achieve phase transition at body temperature only by using poloxamer alone

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • An injection used in vascular anastomosis or intravascular occlusion
  • An injection used in vascular anastomosis or intravascular occlusion
  • An injection used in vascular anastomosis or intravascular occlusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 32 g of poloxamer 407 with an average molecular weight of 9840 and a particle diameter of 1000 microns, add 168 g of purified water, stir and swell at 25 degrees Celsius, and sterilize by isotope irradiation to obtain figure 1 The viscous homogeneous transparent solution shown.

[0035] Evaluation of temperature sensitivity: After heating the injection to 37 degrees Celsius, a uniform transparent gel was obtained, such as figure 2 shown.

[0036] Then lower the temperature to 25 degrees Celsius, and the gel turns into a viscous uniform transparent liquid, such as image 3 shown.

[0037] Warming up to 37 degrees centigrade again, obtain uniform transparent gel again, as Figure 4 shown. After heating, cooling, and reheating process, it can be seen that the injection of this embodiment is a liquid below 25 degrees Celsius and a gel at 37 degrees Celsius, and the product can be changed from a liquid to a gel through the process of cooling, heating, and cooling ...

Embodiment 2

[0050] Weigh 30 g of poloxamer 407 with an average molecular weight of 11,000 and a particle size of 500 microns, add 70 g of purified water, heat and stir at 60 degrees Celsius to swell, use a 0.22 micron filter membrane to filter the heat source online, and obtain a viscous uniform transparent solution.

[0051] Evaluation of injection viscosity at different temperatures:

[0052] Using a viscometer to measure the viscosity of the injection at different temperatures, the results are as follows Figure 9 As shown, when the temperature is lower than 30 degrees Celsius, the viscosity of the injection is 95-105, when the temperature is higher than 30 degrees Celsius, the viscosity starts to increase, and finally reaches 1*10 at 40 degrees Celsius 5 , indicating that its viscosity will change with temperature and is temperature sensitive.

Embodiment 3

[0054] Weigh 54 g of poloxamer 407 with an average molecular weight of 14600 and a particle size of 5 microns, add 146 g of water for injection, heat and stir at 60 degrees Celsius to swell, and sterilize with moist heat to remove the heat source to obtain a viscous uniform transparent solution.

[0055] The above embodiment realizes its phase transformation at 35-40 degrees Celsius, so that it can be used in the implementation of vascular anastomosis or intravascular occlusion, and has dual functions of filling blood vessel stumps and intravascular occlusion. During surgery, it can replace metal hemostatic instruments to achieve the effect of occlusion of blood vessels, and at the same time make blood vessels full,

[0056] Facilitate vascular anastomosis.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to an injection for operations, in particular to an injection applied to blood vessel anastomosis and endovascular occlusion, and belongs to the technical field of medical supplies. According to the injection applied to blood vessel anastomosis and endovascular occlusion provided by the invention, the injection consists of 16%-30% of poloxamer and 70%-84% of water in a proportion by weight. The injection is safe, reliable and nontoxic, has good biocompatibility, takes the principle of not impeding the self-healing of human tissues as a basic starting point, the poloxamer is singly used, phase transformation occurs at 35-40 DEG C is realized, and thus the injection is used during the implementation of blood vessel anastomosis or endovascular occlusion, and the injection has double functions of broken end angioplerosis and endovascular occlusion. During surgical operation, the injection can take the place of a metal hemostasis instrument for achieving the effect of blocking the blood vessels, and meanwhile angioplerosis is realized, and vascular anastomosis is facilitated.

Description

technical field [0001] The invention relates to an injection for operation, in particular to an injection used in vascular anastomosis and intravascular occlusion, and belongs to the technical field of medical supplies. Background technique [0002] At present, the suture method is the most effective method of vascular anastomosis. Whether it is an anastomosis of large vessels (such as the superior and inferior vena cava), small vessels (such as the renal artery), or the anastomosis of the ureter and bile duct, the two anastomotic ports are clamped with vascular clips. Continuous sutures are performed, veins are more difficult to suture than arteries in vascular anastomoses. Further, suturing can be more difficult when there is a large difference in the diameters of both the donor vessel and the recipient portion or when the donor vessel and recipient portion are positioned perpendicular to each other. In addition, in vascular anastomosis, at least one artery and two veins ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04
Inventor 靳翔薛乐珍
Owner YANTAI YENEPHARMA BIOMEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com