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Extract of aceraceous plant and its extracting method and use

An extraction method, the technology of Aceraceae, is applied in the direction of plant raw materials, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., which can solve the problems of limited application value and insufficient inhibitory activity, and achieve high drug efficiency. The effect of using value, high efficiency, and simple extraction method

Inactive Publication Date: 2007-01-24
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common disadvantage of these inhibitors is that the inhibitory activity is not high enough, and the application value is limited, so finding fatty acid synthase inhibitors with high inhibitory activity has important practical application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, the extraction of effective substance in Acer tartar, Acer Norway, Acer slender handle, Acer field, Eurasian maple leaf

[0021] Wash the leaves of Acer tartar, Acer Norway, Acer spp., Acer field, and Acer eurasia collected in October, and then crush them after natural drying or low-temperature drying (<50°C), and extract the effective substances by the following method :

[0022] Use ethanol-water mixed solvent (the percentage by volume of ethanol is 70%) with the above-mentioned pulverized Acer tartar, Acer Norway, Acer slender handle, Acer field respectively, and the dry leaves of Acer eutrophica in parts by weight ratio 20:1 Mix and extract by microwave for 16 seconds. The microwave frequency used is 2450MHz, the microwave output power is 700W, and the duty cycle is 4%. The obtained extract was filtered, and then extracted three times under the same conditions. After filtration, the three filtrates were combined, evaporated and concentrated at a low ...

Embodiment 2

[0023] Embodiment 2, the extraction of effective substance in Acer tartar, Acer Norway, Acer slender handle, Acer field, Eurasian maple leaf

[0024] Wash the leaves of Acer tartar, Acer Norway, Acer spp., Acer field, and Acer eurasia collected in October, and then crush them after natural drying or low-temperature drying (<50°C), and extract the effective substances by the following method :

[0025] Use acetone-water mixed solvent (the percentage by volume of acetone is 60%) to mix with the above-mentioned pulverized Acer tararum, Acer Norway, Acer slender handle, Acer pastoral, Acer eucalyptus dry leaves in parts by weight in a ratio of 25: 1. Combine, transfer to a glass container, and microwave for 12 seconds. The microwave output power is 800W, the microwave frequency is the same as above, and the duty cycle is 5%. Filter the treatment solution, add acetone-water mixed solvent under the same conditions to extract the residue again, repeat 3 times, after filtering, comb...

Embodiment 3

[0027] Embodiment 3, the extraction of effective substance in the Acer tartar, Acer Norway, Acer slender handle, Acer pastoral, Eurasian Acer

[0028] Wash the samaras of Acer tartar, Acer Norway, Acer slender handle, Acer field, and Acer samurai collected in October, dry them naturally or dry them at low temperature (<50°C), and then crush them, and use the following methods to extract effectively thing:

[0029] Use ethanol-water mixed solvent (volume and number ratio of ethanol and water is 60: 40) with above-mentioned pulverized Acer tartar, Norway maple, Acer spp. : 1 mixed, transferred to a glass container, microwaved for 20 seconds, with a microwave output power of 700W, a microwave frequency of 2500MHz, and a duty cycle of 3.6%. Filter the solution, and then extract 3 times under the same conditions. After filtering, combine the three filtrates, (reduced pressure) low-temperature evaporation and concentration, remove the organic solvent, and obtain an aqueous phase co...

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PUM

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Abstract

The present invention discloses a kind of aceraceous plant extract and its extracting process and application. The aceraceous plant extract is extracted from Acer Linn plant in Aceraceae, and through a microwave extraction process with water-ethanol or water-acetone mixture solvent. The aceraceous plant has relatively high fatty acid synthetase inhibiting activity and high medicinal value, and may be applied widely in preparing slimming medicine and cancer treating medicine. The present invention has very short extracting period of aceraceous plant extract, simple extraction process and high efficiency.

Description

technical field [0001] The present invention relates to a plant extract and its extraction method and application; in particular, it relates to the extract of aceraceae (Aceraceae) plant of the genus Acer Linn and its extraction method, as well as the use of the extract in the field of medicine. Background technique [0002] Fatty acid synthase, formerly known as fatty acid synthase, (EC 2.3.1.85, fatty acid synthase, abbreviated as FAS), fatty acid synthase in animals is called type I FAS, fatty acid synthase in prokaryotes and plants is called type II Fas. Basic research at home and abroad has shown that fatty acid synthase is a potential target for therapeutic purposes. [0003] So far, reported fatty acid synthase inhibitors are less, only the synthetic C75 (Kuhaida F.P., PizerE.S., Li J.N., et al.Proc.Natl.Acad.Sci.USA., 97,3450-3454( 2000)), the earlier discovered natural product cerulenin (cerulenin) (Vance D., Goldberg I., Mitsuhashi O. et al. Biochem Biophys Res C...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/04
Inventor 赵文华高春春田维熙张英侠董凌月阳志成黎金龙王耀楠
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES