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Laminated microfluidic structures and method for making

A technology of microfluidic structure and microstructure, applied in the field of microfluidics, can solve problems such as inability to have high yield

Active Publication Date: 2007-01-24
北京博昂尼克微流体技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Necessary control over small volumes of bonded material precludes high yields

Method used

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  • Laminated microfluidic structures and method for making
  • Laminated microfluidic structures and method for making
  • Laminated microfluidic structures and method for making

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Embodiment Construction

[0025] As used herein, the term "microstructure" generally refers to a structural feature on a microfluidic substrate element having a plurality of walls, the walls having at least one dimension ranging from about 0.1 microns to about 1000 microns. These features can be, but are not limited to, microchannels, microfluidic pathways, microreservoirs, microvalves, or microfilters. The term "polymeric" refers to a macromolecular structure or material having a molecular weight significantly higher than that of the constituent monomers and produced by polymerization. All materials generally and herein referred to as "plastic" materials are polymeric materials. The term "acrylic" means Acrylite  、Plexiglas  , PMMA or other trade names for polymethyl methacrylate. "Two-dimensional microfluidic network" refers to the fluidic connectivity of at least two microfluidic pathways or channels co-existing within an element or in the plane of a planar element. "Three-dimensional microflu...

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Abstract

A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

Description

technical field [0001] Embodiments of the present invention are directed to the field of microfluidics in general and, more particularly, to a laminated polymeric microfluidic structure and a method of making a laminated polymeric microfluidic structure. Background technique [0002] The technique of manipulating tiny volumes of biological and chemical fluids is broadly known as microfluidics. Practical and potential applications of microfluidics include disease diagnosis, life science research, biological and / or chemical sensor development, and other applications within the knowledge of those skilled in the art. [0003] A microfluidic structure comprising a substrate with one or more microfluidic channels or pathways and a cover plate or a second or more substrates with fluidic pathways that may or may not communicate with each other may generally be referred to as a microfluidic chip. Highly integrated microfluidic chips are sometimes referred to as "labs on a chip". In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J5/10G01N15/06G01N33/00G01N33/48
CPCB01L3/502707B01L2200/12B29C65/4815B29C66/543B29L2031/756B01L2200/0689B29C65/48B29C65/4895B29C65/483B01L2300/0887B29C66/54B01L2300/0816B29C66/71B29K2069/00B29K2033/08B29K2025/06
Inventor 周朋林肯·C·扬
Owner 北京博昂尼克微流体技术有限公司
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