Pharmaceutical composition and its preparation

A composition and medicine technology, applied in the field of pharmaceutical compositions and their preparation, can solve the problems of different extraction efficiency, unstable cantharidin content, increased white blood cells and the like

Inactive Publication Date: 2007-02-07
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cantharidin is the main active ingredient in mylabris. Cantharidin not only has anti-tumor effect, but also has anti-virus, leukocyte-raising, and estrogen-stimulating effects. During the extraction process, the extraction reproducibility and extraction efficiency of cantharidin are not the same, resulting in unstable cantharidin content in the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] The preparation of the freeze-dried powder for injection of formula one: take 10000g ginseng and 1g cantharidin

[0117] The specific operation is as follows: take the cantharidin medicinal material, pulverize, extract with 10 times the amount of 70% ethanol under heating and reflux, filter, and reserve the medicine residue, adjust the extract to pH 8-9 with sodium hydroxide solution, recover the ethanol under reduced pressure, filter, and add water Dilute, adjust to pH 7 with hydrochloric acid solution, let stand, refrigerate for 24 hours, centrifuge and filter, and adjust the supernatant to pH 8-9 with sodium hydroxide solution to obtain cantharidum extract; take ginseng slices and use 10 times 70% The ethanol is heated and refluxed for extraction, filtered, and the medicine residue is ready for use. The extract is decompressed to recover the ethanol. The concentrated solution is added with water until the ratio of volume to the amount of medicinal materials is about 3:2 ...

Embodiment 2

[0119] Preparation of orally disintegrating tablets of formula one: ginseng 500g, cantharidin 200g

[0120] The specific operation is as follows: take the cantharidin medicinal material, crush, extract with 5 times the amount of 100% ethanol under heating and reflux, filter, and reserve the medicine residue. The extract is adjusted to pH 10 with sodium hydroxide solution, the ethanol is recovered under reduced pressure, filtered, and diluted with water. Adjust the pH to 8 with hydrochloric acid solution, let stand, refrigerate, and filter by centrifugation. The supernatant is adjusted to pH 10 with sodium hydroxide solution, dried under reduced pressure, and crushed into a powder of 200 meshes to obtain Cantharidum extract; take ginseng slices and use 20 The double amount of 90% ethanol is heated and refluxed for extraction, filtered, and the medicine residue is ready for use. The extract is decompressed to recover the ethanol. The concentrated solution is added with water until t...

Embodiment 3

[0122] The preparation of the first group of capsules: ginseng 5000g, cantharidin 150g

[0123] The specific operation is as follows: take the cantharidin medicinal material, pulverize, extract with 30 times the amount of 30% ethanol under heating, reflux, filter, and reserve the medicine residue. The extract is adjusted to pH 7 with sodium hydroxide solution, the ethanol is recovered under reduced pressure, filtered, and diluted with water. Adjust the pH to 6 with hydrochloric acid solution, let stand, refrigerate, and filter by centrifugation. Adjust the supernatant to pH 7 with sodium hydroxide solution, dry under reduced pressure, and pulverize to obtain Cantharidum extract; take ginseng slices and use 4 times the amount 30% The ethanol is heated and refluxed for extraction, filtered, and the medicine residue is ready for use. The extract is decompressed to recover the ethanol. The concentrated solution is added with water until the ratio of volume to the amount of medicinal m...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating tumor and process for preparation, wherein the composition is prepared from gen-seng, Chinese blistering beetle or their extracts or their active constituents. The composition can improve the body's immunity function and suppress tumor cells directly.

Description

Field of invention: [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating tumors and a preparation method thereof, and belongs to the field of medicine technology. technical background: [0002] Tumors have always been a serious disease that endangers human health and even lives. Tumors have caused difficulties in life and physical pain for patients, and brought a series of problems and serious losses to the country. Modern research believes that the occurrence and development of tumors are closely related to the imbalance of the body's cellular immune function. The present invention is an effective traditional Chinese medicine preparation based on this theory that can not only resist tumors but also enhance cellular immune functions. [0003] Cantharis has an anti-tumor effect, and its mechanism of action may be achieved by inhibiting the synthesis of protein and nucleic acid. Cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P35/00A61K35/64
Inventor 叶湘武夏晓辉
Owner GUIZHOU YIBAI PHARMA CO LTD
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