Process of extracting shikimic acid from aniseed

A technology of shikimic acid and star anise, applied in the field of physical separation, can solve problems such as low extraction yield, low resin exchange capacity, serious pollution and the like

Active Publication Date: 2007-03-21
GUANGXI WANSHAN SPICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research and development of shikimic acid extraction and separation using membrane separation technology has not been reported.
This method integrates microfiltration, ultrafiltration and nanofiltration technology of membrane separation, uses star anise as raw material, and uses water as extraction solvent, which has high extraction rate of raw materials, and uses advanced membrane separation equipment to complete the separation and concentration of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 50 kg of star anise medicinal material (the content of the medicinal material is 6%), crush it into a coarse powder, add 250L of water to boil, heat for 1 hour to extract, filter, add 150L of water to boil, heat for 1 hour, then filter, add 100L of water to boil, heat for 1 hour Filter and combine the extracts. The extract is subjected to microfiltration under a pressure of 0.8 MPa. The microfiltration membrane adopts a microporous membrane with a cut-off relative molecular weight of more than 70,000 to remove impurities such as water-soluble protein, pectin, and suspended solids in the solution. The filtrate obtained by microfiltration was subjected to ultrafiltration under a pressure of 1.0 MPa, and a hollow fiber ultrafiltration membrane with a cut-off relative molecular weight of 20,000 was selected to separate shikimic acid from other components. The filtrate obtained by microfiltration was concentrated by sodium filtration under a pressure of 1.5 MPa. When co...

Embodiment 2

[0028] Take 50 kg of star anise medicinal material (the content of the medicinal material is 6%), crush it into a coarse powder, add 250L of water to boil, keep warm for 1 hour to extract, filter, add 200L of water to boil, keep warm for 1 hour, then filter, add 150L of water to boil, keep warm for 1 hour Filter and combine the extracts. The extract is subjected to microfiltration under a pressure of 0.2 MPa. The microfiltration membrane adopts a microporous membrane with a cut-off relative molecular weight of more than 70,000 to remove impurities such as water-soluble protein, pectin, and suspended matter in the solution. The filtrate obtained by microfiltration was subjected to ultrafiltration under a pressure of 0.8 MPa, and a hollow fiber ultrafiltration membrane with a cut-off relative molecular weight of 3000 was selected to separate shikimic acid from other components. The filtrate obtained by microfiltration was concentrated by sodium filtration under a pressure of 1.2...

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PUM

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Abstract

The present invention is membrane separation process of extracting shikimic acid from aniseed, and the process includes the steps of extraction of shikimic acid, separation and purification. Specifically, shikimic acid is extracted with aniseed material and water as solvent and through micro filtering, ultrafiltering, nanofiltering, crystallizing and re-crystallizing in acetone. The present invention has the features of high extracting rate, no waste water draining, short production period, low cost, etc.

Description

technical field [0001] The invention relates to a physical separation method, in particular to a method for extracting and separating shikimic acid from star anise. Background technique [0002] The molecular formula of shikimic acid is C 7 h 10 o 5 , the relative molecular weight is 174.15, the scientific name is 3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid, it is white fine powder, slightly gas, bitter acid, soluble in water, insoluble in chloroform, benzene And petroleum ether, the melting point is 185°C, and the optical rotation is -180°. There are three hydroxyl groups, one carboxyl group, and one double bond in the molecular structure of shikimic acid, and it has chiral isomers. It can form esters or salts. Shikimic acid is an intermediate in the synthesis of biological and metabolic compounds, and it is also a raw material for the synthesis of many alkaloids, aromatic amino acids and indole derivatives, and chiral drugs (such as antiviral drugs). Shikimic ac...

Claims

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Application Information

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IPC IPC(8): C07C62/04C07C51/64A61K36/57A61K131/00
Inventor 刘新伟韦万章
Owner GUANGXI WANSHAN SPICE
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