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Figwort total phenyl glycoside and its prepn process and application

A technology of total phenylpropanoid glycosides and phenylpropanoid glycosides, applied in the field of medicine, can solve problems such as unreported and unreported preparations, and achieve the effects of reducing blood flow in rats and inhibiting the maximum platelet aggregation rate

Inactive Publication Date: 2007-03-21
张惠东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the preparation of the total phenylpropanoid glycosides of Scrophulariaceae as the active ingredient; there is no report on the use of the total phenylpropanoid glycosides of Scrophulariae Scrophulariae for the treatment of thromboangiitis obliterans.

Method used

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  • Figwort total phenyl glycoside and its prepn process and application
  • Figwort total phenyl glycoside and its prepn process and application
  • Figwort total phenyl glycoside and its prepn process and application

Examples

Experimental program
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Effect test

Embodiment 1

[0065] Embodiment 1, the preparation of total phenylpropanoid glycosides of Radix Scrophulariae

[0066] Take 10kg of Scrophulariaceae medicinal material crushed into coarse grains, infiltrate with 30% ethanol for 12 hours, then extract by percolation, collect 200L of percolation liquid, concentrate to 10L, pass through a chromatographic column equipped with 20L of D101 macroporous resin, and then water and 100L of 20% ethanol to remove impurities; then eluted with 100L of 50% ethanol, collected the eluate, concentrated to about 10L, and again adsorbed and eluted by macroporous resin according to the above method, collected the eluate, and concentrated to No alcohol. Adsorbed through a silica gel column, washed with 50L of 20% ethanol to remove impurities, and then eluted with a mixture of ethanol and ethyl acetate (1:1), with a volume of 50L. The eluate was collected, concentrated under reduced pressure, and dried to obtain yellow The brown powder is the total phenylpropanoi...

Embodiment 2

[0067] Embodiment 2, the preparation of total phenylpropanoid glycosides of Radix Scrophulariae

[0068]Cut Scrophulariaceae into thin slices, take 10kg, heat and reflux three times with 60% ethanol 60L, each time for 1 hour, combine the three extracts, concentrate to 15L, and pass through a chromatographic column equipped with 20L of D101 macroporous resin , followed by washing with water and 20% ethanol 200L to remove impurities; then eluting with 50% ethanol 200L, collecting the eluate, concentrating it to about 10L, and then elution through macroporous resin again according to the above method, and collecting the eluate , concentrated to about 10L. Adsorbed through a silica gel column, washed with 100L of 20% ethanol to remove impurities, and then eluted with a mixture of ethanol and ethyl acetate (1:1), with a volume of 100L. The eluate was collected, concentrated under reduced pressure, and spray-dried to obtain The yellow-brown powder is the total phenylpropanoid glyco...

Embodiment 3

[0069] Embodiment 3, the preparation of tablet

[0070] Take 50g of total phenylpropanoid glycosides from Scrophulariaceae, add 50g of compressible starch and 40g of sodium carboxymethyl starch, mix well, use 70% ethanol as a wetting agent, make soft material, granulate with 18 mesh sieve, dry, 16 mesh Sieve and granulate, add 3g magnesium stearate as lubricant, mix uniformly, tabletting, coating, make 1000 coated tablets. Wherein the weight content of the total phenylpropanoid glycosides of Scrophulariaceae is about 35%.

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Abstract

The present invention belongs to the field of medicine preparing technology, and is especially one kind of figwort total phenyl glycoside compound and its preparation process and application. The figwort total phenyl glycoside has main components of angole glycoside C and ergot sterioside in the weight ratio of 90-95 to 5-10 and total content over 80 wt%. It is prepared through hot alcohol extraction or alcohol percolation. Pharmaceutical experiments show that the figwort total phenyl glycoside can reduce the blood rheology of rat obviously, inhibit platelet aggregation of rat and inferior phlebothrombosis of rat, so that it may be used in preparing medicine for thromboangitis obliterans. It and pharmaceutically acceptable carrier may be form medicine composition capable of being prepared into various preparation forms, such as tablet, capsule, granule, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a total phenylpropanoid glycoside compound extracted from the traditional Chinese medicine Scrophulariaceae scrophulariae, a preparation method thereof, and a new application in preparing medicine for treating thromboangiitis obliterans. technical background [0002] Scrophulariaceae is the dry root of Scrophularia ningpoenisis Hemsl., a plant of the family Scrophulariaceae. It is sweet, bitter, salty, slightly cold, and returns to the lung, stomach, and kidney channels. It has the functions of cooling blood and nourishing yin, purging fire and detoxifying, and can be used for febrile disease and yin deficiency, crimson tongue and polydipsia, warm toxin rash, fluid injury and constipation, bone steaming and labor cough, eye irritation and sore throat, diphtheria, carbuncle and sores, etc. Treatment. [0003] The chemical components of Scrophulariaceae are mainly iri...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H13/02A61K31/7028A61K36/808A61P9/10A61P9/00A61K125/00
Inventor 张惠东
Owner 张惠东
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