Purified interleukin-15/fc fusion protein and preparation thereof

A technology of fusion protein and protein, which is applied in the direction of interleukin, peptide preparation method, animal/human protein, etc., and can solve the problems such as the difficulty of rejection
CN1946739AInactive Publication Date: 2007-04-11F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2007-04-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a process for purifying an interleukin-15 / Fc fusion protein from a composition, which process comprises a) applying the composition to an affinity chromatography column and eluting a first IL-15 / Fc eluate from the column and b) applying the eluate of step a) to an ion exchange chromatography column and eluting a second IL-15 / Fc eluate from the column; and to a purified interleukin-15 / Fc fusion protein and a composition, in particular a pharmaceutical composition, comprising such a fusion protein.
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Description

technical field

[0001] The present invention relates to a method of purifying an interleukin-15 / Fc fusion protein from a composition comprising a) applying the composition to an affinity chromatography column and eluting the first IL-15 / Fc elution from the column and b) applying the eluate from step a) to an ion-exchange chromatography column and eluting a second IL-15 / Fc eluate from the column; also to purified interleukin-15 / Fc fusion protein and comprising Compositions of such fusion proteins, especially pharmaceutical compositions. Background of the invention

[0002] Organ or tissue transplantation has become the standard method and, in many cases, the only life-saving treatment for many life-threatening diseases. However, difficulties often arise with respect to rejection of the recipient organ, which is caused by an immune response to foreign cell surface antigens of the graft. One therapeutic approach to inhibit rejection is the suppression of humoral or cellular ...

Claims

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