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Injection medicine for treating cardio-cerebrovascular disease, and its preparing method

A technique for cardiovascular and cerebrovascular injections, which is applied in the fields of cardiovascular system diseases, drug delivery, drug combination, etc., to achieve high stability, ensure clinical efficacy, and good safety

Inactive Publication Date: 2007-06-13
李晓华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the domestic research and use of breviscapine and balsamic are relatively active. However, using the interaction of breviscapine and balsamic volatile components to make compatible prescriptions into drugs for treating cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] The preparation of the volatile component extract of embodiment one dalbergia [one]

[0071] Take 1000g of balsamic medicinal material, add water to infiltrate for 24 hours, steam distill for 5 hours, collect volatile oil of balsamic, about 10ml, to obtain.

Embodiment 2

[0072] The preparation of the volatile component extract of embodiment two dalbergia [two]

[0073] Take 1000g of balsamic medicinal material, add water to infiltrate for 24 hours, steam distill (or redistill again), collect about 1000ml of distillate, and obtain.

Embodiment 3

[0074] The preparation of embodiment three injection

[0075] Take 2.5g of balsamic volatile oil, add 250ml of water for injection, add 25g of polysorbate-80, stir and mix, add 250g of propylene glycol to dissolve, and set aside; take 10g of breviscapine, add 1L of water for injection, and adjust the pH of meglumine to 7.5, Stir to dissolve, the liquid medicine is ultrafiltered through an ultrafiltration membrane with a pore size of 30,000 molecular weight to obtain an ultrafiltrate; slowly add the above-mentioned solution of balsamic volatile oil into the aqueous solution of scutellarin, stir until clarified while adding, and then add bisulfite Dilute 0.75 g of sodium and 0.75 g of sodium sulfite to 5 L with water for injection, adjust the pH to 7.0 with citric acid, filter the drug solution through a membrane with a pore size of 0.22 μm, potting, 10 ml / bottle, and get ready.

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Abstract

The present invention discloses an injection medicine with the functions of curing angiocardiopathy and cerebrovascular disease and its preparation method. It is made up by using (by weight portion) 1-20 portions of breviscapine and 1-5 portions of dalbergia wood volatile oil or 100-500 portions of delbergia wood distilland. It can be used for curing angiocardiopathy and cerebrovascular diseases of myocardial ischemia, angina pectoris, cerebral ischemia and cerebral infarction, etc.

Description

1. Technical field [0001] The invention relates to a drug for injection at the effective part of traditional Chinese medicine with the effect of treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The drug is prepared by combining breviscapine and volatile component extracts of balsamic balsamic, and belongs to the field of traditional Chinese medicine. 2. Background technology [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among urban population, tum...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K31/7048A61K9/08A61K9/14A61P9/10
Inventor 李晓华叶澜杰薛建欣
Owner 李晓华
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