Capsule comprising moguisteine

Abstract

The invention provides a Moggi Stan capsules, its characteristics are: mixing Moggi Stan and hydrophilic substances, disintegrating or abrading together, then mixing them with other excipients, filling capsules after preparing tablets with whole powder method or dry method. It has effects of moisture proof, avoiding light and so on, and can conceal adverse tastes of drug, but also avoids the main drug melting in wet method preparing tablets heating process, while ensures rapid drug absorption and dissolution.

Description

technical field [0001] The invention relates to a non-narcotic antitussive medicine, in particular to a capsule preparation with mogisteine ​​as an active substance. technical background [0002] Antitussives are mainly divided into two categories: central and peripheral. Mogisteine ​​is a peripheral non-narcotic antitussive drug. The clinical effect is similar to that of codeine. Unlike codeine, mogisteine ​​does not act on opioid receptors, but through peripheral receptors, does not cause addiction, and mogisteine ​​has sedative and reduced obligatory spasm responses effect, its higher doses are better tolerated and can be administered to children. [0003] The melting point of mogisteine ​​is about 60°C, and it is easy to cause the main drug to melt during the drying process using the conventional wet granulation process. Mogistein has low solubility in water, which easily leads to low bioavailability of the prepared oral solid preparation. Mogisteine ​​has a severe b...

AI Technical Summary

Problems solved by technology

At present, β-cyclodextrin inclusion and solid dispersion technology are mostly used to mask the taste, but the conditions are not easy to control, and the final product must be verified by special means, and the process is complicated

The method of adding flavoring agents in the composition does not play a big role when some raw materials have a strong bitter taste

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