N-substituted piperidines and their use as pharmaceuticals

A pharmaceutical and prodrug technology, applied in the field of modulators of 11-beta hydroxysteroid dehydrogenase type 1 and/or mineralocorticoid receptors, which can solve problems such as blindness and visual field loss
CN1993128AInactive Publication Date: 2007-07-04INCYTE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INCYTE
Publication Date
2007-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-beta hydroxyl steroid dehydrogenase type I and / or diseases associated with aldosterone excess.
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Description

field of invention

[0001] The present invention relates to modulators of 11-beta hydroxysteroid dehydrogenase type 1 (11βHSD1) and / or the mineralocorticoid receptor (MR), compositions thereof, and methods of using the same. Background of the invention

[0002] Glucocorticoids are steroid hormones that regulate fat metabolism, function and distribution. In vertebrates, glucocorticoids also have profound and diverse physiological effects on growth, neurobiology, inflammation, blood pressure, metabolism, and apoptosis. In humans, the major endogenous glucocorticoid is cortisol. Cortisol is synthesized in the zona fascicularis of the adrenal cortex and is controlled by a short-term neuroendocrine feedback loop known as the hypothalamic-pituitary-adrenal (HPA) axis. Adrenal production of Cortisol is under the control of adrenocorticotropic hormone (ACTH), a factor produced and secreted by the anterior pituitary gland. ACTH production in the anterior pituitary is itself highly ...

Claims

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