Process for producing wet ribavirin pellets
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[0016] The present invention discloses a process for making pharmaceutical dosages of ribavirin through wet granulation. There are several formulas that can be utilized to produce ribavirin pellets by wet granulation, preferably with extrusion and spheronization. TABLE 1% Range ofFormulation IngredientTotal FormulationFunction in the Formulationribavirin31-35Active PharmaceuticalIngredientmicrocrystalline cellulose 27-35.5Binder / Diluentcroscarmellose sodium0-3Disintegrantpolyethylene glycol11-39Binder / Wetting Agent
[0017] Under one of the preferred embodiments, the dry ingredients listed in Table 1 above are mixed together and granulated with the wetting agent, extruded through a screen (0.4 millimeter (“mm”) to 1.0 mm), spheronized, and fluid bed dried. Depending on the dosage required, the resulting pellets are filled into hard gelatin capsules sizes “1” to “00.”TABLE 2% Range ofFunction in theFormulation IngredientTotal FormulationFormulationribavirin, U.S. Pharmaceutical41-67Ac...
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