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Electrochemical test strip for reducing the effect of direct interference current

a technology of direct interference current and test strip, which is applied in the field of electrochemical strips, can solve the problems of unsatisfactory oxidation current, reduce the oxidation current, and the technique is not always successful, and achieve the effect of more accurate results

Inactive Publication Date: 2005-06-23
LIFESCAN SCOTLAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0064] One advantage of the present invention is the ability to use the first and second working electrode to determine that the sample receiving chamber has been sufficiently filled with liquid. It is an advantage of this invention in that the second working electrode not only corrects the interferent effect, but can also measure. glucose. This allows for a more accurate results because 2 glucose measurements can be averaged together while using only one test strip.
is the ability to use the first and second working electrode to determine that the sample receiving chamber has been sufficiently filled with liquid. It is an advantage of this invention in that the second working electrode not only corrects the interferent effect, but can also measure. glucose. This allows for a more accurate results because 2 glucose measurements can be averaged together while using only one test strip.

Problems solved by technology

In particular, desirable oxidation current results from the interaction of the mediator with the analyte of interest (e.g., glucose) while undesirable oxidation current is generally comprised of interfering compounds being oxidized at the electrode surface and by interaction with the mediator.
However, this technique is not always successful since some interfering compounds such as acetaminophen do not have a net negative charge, and thus, can pass through a negatively charged membrane.
Nor would this technique reduce the oxidation current resulting from the interaction of interfering compounds with some mediators.
However, such selective membranes typically make the test strip more complicated to manufacture and increase the test time because the oxidized glucose must diffuse through the selective membrane to get to the electrode.
A disadvantage of this strategy is that mediators having a relatively low potential are often difficult to synthesize, unstable and have a low water solubility.
A disadvantage of this strategy is that it requires that the test strip include an additional electrode and electrical connection (i.e., the dummy electrode) which cannot be used to measure glucose.
The inclusion of dummy electrode is an inefficient use of an electrode in a glucose measuring system.

Method used

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  • Electrochemical test strip for reducing the effect of direct interference current
  • Electrochemical test strip for reducing the effect of direct interference current
  • Electrochemical test strip for reducing the effect of direct interference current

Examples

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example 1

[0065] Test strips were prepared according to the first embodiment of the present invention as illustrated in FIG. 1 to 3. These test strips were tested in blood having various concentrations of interferents. To test these strips, they were electrically connected to a potentiostat which has the means to apply a constant potential of 0.4 volts between the first working electrode and the reference electrode; and the second working electrode and the reference electrode. A sample of blood is applied to the sample inlet allowing the blood to wick into the sample receiving chamber and to wet first working electrode, second working electrode, and reference electrode. The reagent layer becomes hydrated with blood and then generates ferrocyanide which may be proportional to the amount of glucose and / or interferent concentration present in the sample. After about 5 seconds from the sample application to the test strip, an oxidation of ferrocyanide is measured as a current for both the first a...

example 2

[0068] To show that the method of correcting the current for interferents applies to a wide variety of interferents, strips built according to the embodiment of FIG. 1 were also tested with acetaminophen and gentisic acid at various concentration levels, in addition to uric acid. For purposes of quantitating the magnitude of this effect, a change in glucose output of greater than 10% (for glucose level >70 mg / dL) or 7 mg / dL (for glucose level <=70 mg / dL) was defined as a significant interference. Table 1 shows that the uncorrected current at the first working electrode shows a significant interferent effect at a lower interferent concentration than strips tested with a corrected current response using Equation 7a. This shows that the method of correcting the current output of the first working electrode using Equation 7a is effective in correcting for interferences. Table 1 shows that the current correction in Equation 7a is effective for interferences with respect to acetaminophen,...

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Abstract

This invention describes an electrochemical sensor which is adapted to reduce the effects of interfering compounds in bodily fluids when measuring an analyte in such fluids using an electrochemical strip. The sensor includes a substrate, a first and second working electrodes, and a reference electrode. A reagent layer is disposed on the electrodes such that, in one embodiment it completely covers all of the first working electrode, but only partially covers the second working electrode and, in a second embodiment, it only covers a portion of the first and the second working electrode. The portion of the working electrodes not covered by the reagent layer and is used to correct for the interference effect on the analyte measurement.

Description

PRIORITY [0001] The present invention claims priority to the following U.S. Provisional Applications: U.S. Provisional Application Ser. No. 60 / 516,252 filed on Oct. 31, 2003; U.S. Provisional Application Ser. No. 60 / 558,424 filed on Mar. 31, 2004; and U.S. Provisional Application Ser. No. 60 / 558,728 filed on Mar. 31, 2004. Which applications are hereby incorporated herein by reference. RELATED APPLICATIONS [0002] The present invention is related to the following co-pending U.S. applications: U.S. patent application Ser. No. ______ [Attorney Docket Number DDI-5027 USNP], filed on Oct. 29, 2004; U.S. patent application Ser. No. ______ [Attorney Docket Number DDI-5042 USNP], filed on Oct. 29, 2004; U.S. patent application Ser. No. ______ [Attorney Docket Number DDI-5065], filed on Oct. 29, 2004; U.S. patent application Ser. No. ______ [Attorney Docket Number DDI-5066], filed on Oct. 29, 2004; and U.S. patent application Ser. No. ______ [Attorney Docket Number DDI-5067], filed on Oct. 2...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/00A61B5/145C12Q1/00G01N27/26G01N27/403G01N27/416G01N27/49G01N33/487G06F19/00
CPCA61B5/1411A61B5/14532G01N27/3274C12Q1/001C12Q1/006A61B5/1486A61B5/150022A61B5/150358A61B5/150282A61B5/150435A61B5/150503Y02A90/10G01N27/416G01N27/49G01N33/487
Inventor DAVIES, OLIVER WILLIAM HARDWICKEMARSHALL, ROBERTBASKEYFIELD, DAMIAN EDWARD HAYDONWHYTE, LYNSEYLEIPER, ELAINE
Owner LIFESCAN SCOTLAND
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