Metallic implant and process for treating a metallic implant

a technology of metallic implants and metal coatings, applied in the field of biocompatibility of metallic bone implants, can solve the problems of ultimate failure of implants, brittle ceramic coatings, and functional parts of implants that cannot be attached, and achieve the effect of improving biocompatibility

Inactive Publication Date: 2005-07-28
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0043] According to a sixth aspect a metallic implant with a fluoride or fluorine containing surface may be

Problems solved by technology

A prolonged healing period is however still considered necessary since any movements of the implant in the weeks and months following surgery may endanger the final attachment of the implant to the bone tissue.
However, the fact that the implant may not be loaded means that the fun

Method used

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  • Metallic implant and process for treating a metallic implant
  • Metallic implant and process for treating a metallic implant
  • Metallic implant and process for treating a metallic implant

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] Seven surgical implants, commercially pure (c.p.) titanium, 5 mm in length and generally conical in shape having a diameter at one end of 3 mm and at the other end 2 mm, were prepared by machining using a “Maximat super 11”™ turning lathe. Therefore the area of the conical sides of the implant, i.e. the part of the implant to be located in the bone, is 39 mm2.

[0052] Each implant was cleaned according to a well-known cleaning procedure involving the following steps: [0053] 1. Treatment with trichloroethylene with ultrasonic treatment, for 15 minutes. [0054] 2. Rinsing in absoute ethanol, for 10 seconds. [0055] 3. Three successive treatments with ethanol with ultrasonic treatment, each for 10 minutes.

[0056] Each cleaned implant was sterile packaged in a Mediplast™ sterile envelope, and autoclaved in a Citomat 162™ (LIC Company) autoclave, at 120 C for 30 minutes.

[0057] A HF bath was prepared simply by diluting concentrated HF with distilled water, to give 0.2% solution. The ...

example 2

[0067] Reference implants were made of titanium grade 3, and were made by turning at an average speed of about 7 meters per minute. No cutting fluid was used. The cutting tool was made of high speed steel.

[0068] The reference implant surface was cleaned by a standard cleaning procedure involving the following steps: [0069] 1. Treatment with trichloroethylene with ultrasonic treatment for 15 minutes. [0070] 2. Rinsing in absolute ethanol for 10 seconds. [0071] 3. Three successive treatments with ethanol with ultrasonic treatment, each for 10 minutes. Each cleaned implant should then be sterile package in a Mediplast™ sterile envelope and autoclaved in a Citomat 62™ (LIC Company) autoclave at 120° C. for 30 minutes.

[0072] The result of an experiment in which the force necessary for removing (pushing out) substantially conical, unthreaded implants treated in 0.2% aqueous solution of hydrofluoric acid at room temperature for different time periods is illustrated in the diagram in FIG....

example 3

[0081] Another way of describing the effect of treatment is by means of the induction of Calcium Phosphate Precipitation. This is an in vitro test described in “Damen, Ten Cate, Ellingsen, Induction of Calcium Precipitation by titanium Dioxide, Journal of Dental Research, October 1991”. In this method an implant is immersed in a saturated solution of calcium phosphate. Depending on the surface, precipitation of calcium onto the implant occurs. The concentration of Ca++ is monitored and the time delay (the induction time) until precipitation occurs is measured. The rationale behind this test is the assumption that there is a correlation between the affinity of the implant surface towards the calcium ions and the biocompatibility of the implant surface in bone tissue. The results of the test are illustrated in the appended diagrams, FIGS. 7-10. The concentration of Ca++ is given on the Y-axis (2.00e-1 means 2.00×10−1 etc). The test time is given on the X-axis in minutes.

[0082] The im...

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Abstract

A process for treating a metallic implant consisting essentially of treating the metallic implant with a solution of hydrofluoric acid, which solution has a pH between 1.6 and 3.0.

Description

[0001] This application is a continuation-in-part of U.S. Ser. No. 08 / 446,675, filed Sep. 20, 1996, which is a national phase of application PCT / SE94 / 01225, filed Dec. 19, 1994, which are hereby incorporated by reference.TECHNICAL FIELD [0002] The present application relates to biocompatible metallic bone implants, preferably made of titanium or an alloy thereof, and to a method for treating metallic implants to enhance their biocompatibility. BACKGROUND [0003] A commonly used method for implanting metallic implants into bone tissue is a two stage procedure involving in a first operation surgically placing the implant into the bone tissue, where it is then allowed to rest unloaded and immobile for a healing period of three months or more in order to allow the bone tissue to grow onto the implant surface so as to permit the implant to be well attached to the bone tissue, the cut in the soft tissue covering the implant site being allowed to heal over the implant, and in a second opera...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61L27/06A61L27/54
CPCA61F2310/00023A61K33/16A61L2300/106A61L27/54A61L2300/102A61L27/06
Inventor ELLINGSEN, JAN EIRIKROLLA, GUNNAR
Owner ASTRAZENECA AB
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