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Combinatorial synthesis

a technology of combinatorial synthesis and synthesis, applied in the field of combinatorial synthesis, to achieve the effect of lightly punched and ready-to-punch

Inactive Publication Date: 2005-12-08
MOINI AHMAD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides methods for preparing and using \"libraries\" of composite compositions. These libraries can be used to screen for useful properties by applying individual components to different regions on a substrate or by creating continuous gradients of components on the substrate. The invention allows for the parallel synthesis of large numbers of novel compositions and the analysis of individual samples. The invention also provides delivery systems for depositing small amounts of each component onto a substrate, resulting in uniform distribution and screening of the compositions. The composite libraries can be generated using one or more coatings in the form of continuous concentration gradients or by applying individual components to predefined regions on the substrate. The invention allows for the generation of libraries with millions of potential compositions."

Problems solved by technology

Any heating step, however, is not for the purpose of reacting one deposited layer or component with a contiguous layer, component, or the substrate to form a reaction product.

Method used

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Examples

Experimental program
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examples

General

[0074] For the following examples, ceramic sheets obtained from Mistler (Morrisville, Pa.), were made from a cordierite powder mixed with a binder and tape-cast into a 6½″ voll with a thickness of 0.047″. These squares subsequently require a heating procedure to both remove the binder and provide rigidity to the piece. The cordierite sheets were placed onto a flat surface lightly dusted with powdered cordierite, and placed into a furnace with the following profile: room temperature to 932° F. over 1-6 hours, hold for ½ hour, ramp to 2100-2300° F. over 1-7 hours, hold for 0.5-12 hours, then cool slowly to room temperature. Longer heating times than those listed here are generally acceptable.

[0075] Examples of other tapes useful for this application are a 100% alumina tape and a 96% alumina / 4% glass (magnesium aluminum silicate). An alumina marketed under Alcoa A-16SG is useful. The alumina tapes have a similar thickness to the cordierite tapes. The 96% alumina tapes range in...

examples 1-16

[0078] A standard carrier used in the following experiments had the following formulation: [0079] 1.1 wt % N100 Ethyl Ether Cellulose (Hercules-Aqualon N100 grade) dissolved overnight in a 1:1 mixture of a-Terpineol (Aldrich) and Texanol (American Chemicals).

[0080] The following formulations are examples only. The possible variations are not limited to this list. Also prepared and used were other carriers with the following formulations. These variations were used to change the viscosity and solids loading of the final inks. [0081] (1) 1.1 wt % N50 Ethyl Ether Cellulose (Hercules-Aqualon N50 grade) dissolved in a 1:1 mixture of a-Terpineol (Aldrich) and Texanol (American Chemicals) [0082] (2) 1.1 wt % N300 Ethyl Ether Cellulose (Hercules-Aqualon N300 grade) dissolved in a 1:1 mixture of a-Terpineol (Aldrich) and Texanol (American Chemicals) [0083] (3) 0.55 wt % N100 Ethyl Ether Cellulose (Hercules-Aqualon N100 grade) dissolved in a 1:1 mixture of a-Terpineol (Aldrich) and Texanol (...

example 17

[0089] A spray gun was used to spray coat four different catalyst slurries onto the cordierite sheet. The following four slurries and the corresponding masks (referring to FIG. 2) were used: Zeolite Y (mask A), Cu-ZSM-5 (mask B), Pt—Al2O3 (mask C), and CeO2 (mask D).

[0090] After the spray coatings were completed, there were sixteen individual and unique areas of the cordierite sheet with different coatings. The coated sheet was calcinated to 1000° F. for 2 hours to remove any moisture and organic components.

[0091] Circular sections were drilled out of the sheet in the various unique areas. The drill bit used was a diamond-tipped coring bit with an I.D. of 3.89 mm. The coatings held up very well under the drilling process, and minimal flaking and damage was observed under an optical microscope. The diameter of the circular sections ranged between 3.5 and 3.6 mm.

[0092] The goal was to deposit approximately 0.0075 g / in2 of each of the four slurries. The resulting coatings for the fo...

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Abstract

Methods are disclosed for providing a library of composite compositions on a support. The method involves depositing one or more components onto the support on either discrete spaced regions of the support or as a continuous concentration gradients on the surface of the support. The composite samples can be removed from the support by drilling out portions of the coated support so as to yield individual composite tablets containing the support with one or more component layers thereon. By using this method, a vast number of composites can be made and tested simultaneously.

Description

FIELD OF THE INVENTION [0001] This invention is directed to a method for preparation of large numbers of composite materials suitable for combinatorial screening. Depositing individual components of the composites onto sheets using various coating techniques forms the composites. Either numerous discrete regions on the sheet are coated with a different composition, or large portions of the sheet are provided with one or more coatings which form continuous concentration gradients along one or more axes of the sheet. Composite samples containing one or more components attached to the sheet are then cut or otherwise removed from different regions of the coated sheet and screened for any number of useful properties including, but not limited to, physical, electrical, and chemical properties and any numerous subsets of such properties. BACKGROUND OF THE INVENTION [0002] Combinatorial Chemistry, also known as High Throughput Experimentation, is an emerging area that has impacted various f...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01J19/00B01J37/00G01N35/02C40B30/08C40B40/14C40B40/18C40B60/14G01N35/10G01N37/00
CPCB01J19/0046B01J2219/0043B01J2219/00432B01J2219/00475B01J2219/00518B01J2219/00527B01J2219/00585B01J2219/0059B01J2219/00596B01J2219/00605B01J2219/0061B01J2219/00612B01J2219/00637B01J2219/00659B01J2219/00722B01J2219/00745B01J2219/00747B01J2219/00754C40B30/08C40B40/14C40B40/18C40B60/14Y10T428/24479
Inventor MOINI, AHMADKOERMER, GERALD STEVENCASTELLANO, CHRISTOPHER R.
Owner MOINI AHMAD
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