Novel method for chromatographic finger printing and standardization of single medicines and formulations

Abstract

The present invention provides a method for the chromatographic fingerprinting, chemical and therapeutic standardization, bar-coding of the fingerprints and preparation of a data base for Enterprise Resource Planning (ERP) and Customer Relationship Management (CRM) machines and applications of medicines in general and traditional medicines in particular; this invention includes a software based instrumental method and a novel method of fingerprinting and standardization is proposed for the above purpose and the said method for the chromatographic finger printing which facilitates to correlate the traditional therapeutic standardization methods with the chemical properties of the medicines and humors and provides a rational basis to understand the methods used for the said purpose.

Description

TECHNICAL FIELD [0001] The present invention relates to a novel method of chromatographic finger printing useful for chemical and therapeutic standardization. More particularly, the present invention relates to chromatographic fingerprinting of organic and organo-metallic molecules which have UV-Visible radiation absorptive property present in a plant, animal or any other source capable of being used as a single or formulated medicine. The invention facilitates bar coding of one or many constituents present in the finger print images. It also facilitate commercial utilization of the fingerprint database having all the information about the medicines, development and using ERP (Enterprise Resource Planning) and CRM (Customer Relationship Management) net work applications like vending machines etc. [0002] The present invention employs a novel method of the utilization of the Contour and 3D chromatograms of an herbal medicine and formulation developed under standardized experimental (c...

AI Technical Summary

Benefits of technology

[0107] Still another objective of the present invention is to provide a novel method for chromatographic fingerprinting of herbal medicines useful for the quick identification of the actual profile of the compounds present in the medicine under use along with their therapeutic efficacy of the constituents.

[0247] In yet another embodiment of the present invention relates to a method to attach the display windows with the respective barcodes, facilitating to deal with display windows in all applications whenever they are used as a source of data and information.

Problems solved by technology

On the other hand, it was realized that the biological phenomena could not be universally explained by mechanical means as each individual varies in his basic constitution i.e., Prakruthi that must be kept in mind while prescribing diet or drug to the patient.

Identical requirements for the assessment of old and new combinations would result in inappropriate assessment of certain traditional medicines.

This makes it clear that standardization and therapeutic efficacy of any medicine for which all the constituents are not taken into consideration is futile.

Practically, it will be difficult to provide a rational justification for any mechanism to explain, using this method.

Mostly due to lava floated over a forest destroying flora and fauna.

Nevertheless, in the entire globe, the geological variations may not produce same molecules in all samples collected from different parts of the world.

Although there are traditional methods of identification of medicinal plants like organoleptic, microscopic and physical, none of them gives an authentic identification, as given by a fingerprint of the plant material, as far as the chemical profile is concerned.

Without a standard reference material, the analysis has no meaning because the peak of the chromatogram does not provide any kind of chemical properties of the compound eluted.

If the sample is 100% pure and if it is a known molecule then the analysis at a fixed wavelength is acceptable, but it is highly impractical in the case of medicines where in more than one active molecule are present.

None of the single chromatogram is able to provide complete information about the chemical properties of the constituents present in the medicine particularly in traditional medicines where more than one active principle may be existing.

Hence, any chromatogram presented at a specific wavelength is not able to provide the complete chemical profile of the ingredients present in a single medicine and a formulation.

So, the chromatogram is partial in its report, and is not acceptable.

Any analytical method, which is not giving complete information of the analysis, is not scientifically acceptable.

Hence, the concept of searching for an active ingredient is said to be incomplete, because it is the total profile that is responsible for the medicinal property of the medicine.

So, any analytical method, which does not speak about the complete chemical properties of all of the constituents present in the medicine under study, will not be useful.

But this art of reading Nadi (Pulse) was confined to some people of high caliber, personal skill and ability with lot of discipline.

Hence, every traditional practitioner was not able to practice it.

In other words, harmony of tridoshas bestows good health, disharmony results to disease.

The decrease of vata leads to general dullness in activity.

The decrease of liquidity or mucous will lead to roughness, an internal burning, an emptiness in stomach, a looseness in the joints, thirst, weakness and a continues insomnia.

This concept is in no way going to help the traditional medical practitioners since the isolation of the active principle(s) drastically change the holistic character of the medicines and their therapeutic efficacy.

But all the above studies are costly and time consuming.

This will make the effectiveness of the drug limited to a particular group or genetic type of people.

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