Remedy

Abstract

It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.

Description

TECHNICAL FIELD [0001] The present invention relates to a remedy to normalize macrophages with dysfunction by taking advantage of the phagocytic capacity of macrophages, or effective for various infectious pathogens. The remedy according to the invention is aimed at all substances given on a therapeutic and / or diagnostic basis and assemblies thereof, and a formulation thereof is a medical mixture of a medicament (including a medicament carrier in some cases) and the medicament carrier. BACKGROUND ART I. Macrophage [0002] First, a macrophage which plays a central function in an action of a remedy according to the invention is reviewed. [0003] Morphology and functions of the macrophage are described in detail, for example, in “Seimei o sasaeru Macrophage (Macrophage Which Supports Life)” authored by Kiyoshi Takahashi (Bunkodo, 2001), and the background related to the invention is as follows. The macrophage is a cell which configures a mononuclear phagocyte system (MPS). A monocyte in...

AI Technical Summary

Benefits of technology

"The patent text describes a new remedy for diseases caused by dysfunctional macrophages or by making them a vehicle for pathogens. The remedy aims to exterminate the macrophages infected with pathogens or act upon them in a dysfunctional state. It facilitates the phagocytic activity of macrophages and exterminates the pathogens in them. The remedy can be used for diseases such as mycobacteriosis, AIDS, chlamydiosis, toxoplasmosis, Crohn's disease, rheumatoid, cancer, or immunodeficiency syndrome. It can also be used for diseases caused by the dysfunction of macrophages in mucosal tissues or brain substance. The remedy contains PLGA and can be formulated as fine particles that are actively phagocytosed by macrophages. It is desirable to further contain other substances such as PVA, PEG, PEO, sugar, protein, peptide, phospholipid, or cholesterol to make the remedy more effective."

Problems solved by technology

Therefore, failure of function of the phagocytosis or the antigen presentation of the macrophages can primarily become a potential cause of immunodeficiency.

Furthermore, a mammal with deficiency of the acquired immune system can exist and live, but the animal with deficiency of the macrophage cannot exist.

It is a matter of course that the pathogen which has succeeded to parasitize in the macrophage in this way causes an infectious disease chronically and repeatedly, and it is not unusual to result in a fatal consequence.

However, once the infection is established, there is no effective therapy.

Even if a compound having a direct disinfection action against the infectious pathogen is present, in general it is not easy to accomplish a concentration in the macrophage with the pathogen, which is sufficient to exterminate the specific pathogen (exterminating in the invention means that all or a part of the pathogens are exterminated to vanish.) by simply administering an appropriate remedy.

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