Biologically active oils

a technology of bioactive oils and fatty acids, applied in the field of fungal metabolism/transformation of lipid substrates, can solve the problems of inability to validate claims, inability to reproduce efficacy and safety data of these types of products, and inability to achieve the effect of reproducing efficacy and safety data, and lowering the dose of steroids

Inactive Publication Date: 2006-08-17
TURNER ATHOL GILLIES
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  • Summary
  • Abstract
  • Description
  • Claims
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Benefits of technology

[0062] The biologically active oils produced have also been noted to synergistically enhance the efficacy of a variety of pharmaceuticals including dexamethasone and prednisone. Such synergy is of great clinical benefit as raised levels of pro-inflammatory leukotrienes or 5-lipoxygenase are associated not only with a

Problems solved by technology

However, due to recent adverse publicity by the press and government regulators there is an absolute requirement for alternative medicines to meet strict guidelines regarding the quality of the raw materials and the method of manufacture.
One of the major difficulties with alternative medicines is that the ingredients used are often composed of materials which in most cases may contain many different chemical compounds.
Hence there is an enormous challenge involved to ensure efficacy and safety of the products for use by society.
One of t

Method used

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Examples

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examples

A) Preparation of Topical Medicaments Using Biologically-active Oils

[0086] Examples of creams for topical application were prepared according to the following protocols:

Formulation 1COMPO-SITIONDESCRIPTION(% w / w)PHASE AWaterWater52.475GlycerolGlycerol3.000Disodium EDTADisodium EDTA0.100Stabileze QM ™Poly(methyl vinyl ether / maleic0.350anhydride) decadiene crosspolymerPHASE BOilBiologically-active oil30.000Prolipid 141 ™Emulsifier blend of stearic acid, behenyl5.000alcohol, glycerol-monostearate, lecithin,C12-C16 alcohols and palmitic acidCerasynt 840 ™PEG-20 stearate1.000Ceraphyl 230 ™Di-isopropyl adipate4.000Vitamin E acetateVitamin E acetate0.200PHASE C10% w / v NaOHSodium hydroxide0.875WaterWater2.000PHASE DLiquapar Optima ™Phenoxyethanol, methylparaben,1.000Isopropylparaben, isobutylparabenbutylparabenTotal100.000

Manufacturing Procedure [0087] 1. In phase A combine water and glycerol, and mix well [0088] 2. Sprinkle Stabileze QM™ into the pre-mixed solution with stirring at ro...

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Abstract

A process for the production of fats or oils and their extracts containing biologically-active chemical compounds from a lipid substrate, the process comprising: a) inoculation of a lipid substrate with fungally derived lipolytic enzymes b) incubating the inoculated substrate for a period of between about 7-120 days at a temperature of between about 4-35° C., at a humidity of between about 75-100%, and C) processing said substrate mixture to obtain a biologically active fat or oil.

Description

TECHNICAL FIELD [0001] The present invention relates to fungal metabolism / transformation of lipid substrates to produce fats and more particularly oils and their extracts containing biologically-active chemical compounds for the treatment or prophylaxis of diseases, disorders or conditions in humans and other animals. BACKGROUND OF THE INVENTION [0002] With the growth of the alternative / complementary medicine industry and the general perception in some areas that the products are “snake oil” remedies, there is a pressing need to ensure that products supplied by this alternative industry have reproducible efficacy and are safe for use by the general public. However, due to recent adverse publicity by the press and government regulators there is an absolute requirement for alternative medicines to meet strict guidelines regarding the quality of the raw materials and the method of manufacture. One of the major difficulties with alternative medicines is that the ingredients used are oft...

Claims

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Application Information

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IPC IPC(8): A61K31/22A61K31/202C12P7/64A61K31/20C11B1/02C11B1/06C11B1/10C11B1/12C11B3/00C11B3/12C12P1/02
CPCA61K31/20C11B1/025C11B1/06C11B1/10C11B1/102C11B1/12C11B3/006C11B3/008C11B3/12C12P1/02C12P7/6463A61K36/06C12P7/64A61P1/04A61P11/00A61P11/06A61P17/06A61P19/02A61P29/00A61P3/10A61P35/00A61P43/00A61P9/10
Inventor TURNER, ATHOL GILLIES
Owner TURNER ATHOL GILLIES
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