Method for modulating gene expression in epithelial cells
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- GLIAMED
- Publication Date
- 2007-01-11
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
[0001] This application is a divisional of U.S. Ser. No. 10 / 290,657 which was filed on Nov. 8, 2002.BACKGROUND OF THE INVENTION
[0002] Healing of wounds in skin and other epithelia involves a complex set of interactions between numerous components, including epithelial cells, peripheral nerves, and immune cells, as well as soluble and matrix molecules contributed by the various cell types (reviewed in Hom et al., Growth factor therapy to improve soft tissue healing. Facial Plast. Surg., 18:41-52, 2002). Dysfunctions associated with one or more of these components can lead to anatomical changes of intact skin and / or alterations in the ability of wounded epithelium to regain its normal histology and function. For example, sensory denervation of skin results in alterations in skin anatomy, including thinning of the epidermis, decreases in epidermal proliferation, and changes in the gene expression of Langerhans cells (Huang et al., Influence of cutaneous nerves on keratinocyte prolifer...