Small Peptides And Methods For Treatment Of Arthritis

a small peptide, arthritis technology, applied in the direction of peptide/protein ingredients, immunological disorders, drug compositions, etc., can solve the problems of affecting the inflammatory response, so as to prevent the involvement of the inflammatory response. , the effect of increasing the inflammatory respons
US20080214472A1Inactive Publication Date: 2008-09-04HOUCK JOHN C +2
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
HOUCK JOHN C
Publication Date
2008-09-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting the migration of T-cells. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
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Description

RELATED APPLICATIONS

[0001] This application is a Division of U.S. application Ser. No. 10 / 147,633 filed May 16, 2002, which is a Division of U.S. application Ser. No. 09 / 190,043 filed Nov. 10, 1998 and issued as U.S. Pat. No. 6,391,856 which claims priority from Provisional Application Ser. No. 60 / 065,336 filed Nov. 13, 1997.FIELD OF THE INVENTION

[0002] This invention relates to small peptides having mast cell degranulation inhibition activity and to methods for treating inflammation, and particularly to N-formyl-methionyl peptides useful for the treatment of allergies such as allergic rhinitis, uticaria, anaphylaxis, drug sensitivity, food sensitivity, and the like, cutaneous inflammation such as dermatitis, eczema, psoriasis, contact dermatitis, sunburn, aging, and the like, and arthritis such as osteoarthritis, psoriatic arthritis, lupus, spondylarthritis, and the like. These peptides also are useful for treating chronic obstruction pulmonary disease and chronic inflammatory bowel ...

Claims

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