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Composition for prophylaxis or treatment of urinary system infection and method thereof

a technology for urinary system infection and composition, applied in the direction of biocide, drug composition, antibacterial agent, etc., can solve the problems of limited infection, never used mmp inhibitor in terms of urinary system infection, etc., and achieve the effect of prophylaxis or treatmen

Inactive Publication Date: 2009-07-02
LIN CHIH HSIUNG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition effectively reduces antibiotic resistance, enhances host defense, and provides anti-inflammatory effects, making it suitable for prophylaxis and treatment of recurrent urinary system infections, including urethritis, cystitis, and pyelonephritis, with demonstrated efficacy in clinical examples.

Problems solved by technology

Such infection may be limited to the growth of bacteria in the urine, which frequently may not produce symptoms.
However, MMP inhibitor was never used in terms of urinary system infection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Composition of the Invention (I)

[0054]To provide the composition for prophylaxis or treatment of urinary system infection, the active component was formulated with suitable pharmaceutically acceptable excipients such as lactose, sorbitol, mannitol, magnesium stearate, and the like. The active component was:

Astilbin Extract: 130 mg / tablet or sachet bag.

[0055]The above formulation was processed into tablets or sachet bags with commercial machine.

example 2

Preparation of Composition of the Invention (II)

[0056]To provide the composition for prophylaxis or treatment of urinary system infection, the active components were formulated with suitable pharmaceutically acceptable excipients such as lactose, sorbitol, mannitol, magnesium stearate, and the like. The active components were:

Astilbin Extract: 130 mg / tablet or sachet bag, and

Chlorogenic acid Extract: 60 mg / tablet or sachet bag

[0057]The above formulation was processed into tablets or sachet bags with commercial machine.

example 3

Preparation of Composition of the Invention (III)

[0058]To provide the composition for prophylaxis or treatment of urinary system infection, the active components were formulated with suitable pharmaceutically acceptable excipients such as lactose, sorbitol, mannitol, magnesium stearate, and the like. The active components were:

Cranberry extract: 150 mg / tablet or sachet bag,

Vitamin C: 70 mg / tablet or sachet bag,

Astilbin Extract: 130 mg / tablet or sachet bag, and

Chlorogenic acid Extract: 60 mg / tablet or sachet bag.

[0059]The above formulation was processed into tablets or sachet bags with commercial machine.

Method to Produce the Product:

[0060]Lactose and mannitol were used as excipients; silicon dioxide and magnesium stearate were used as adjuvants. First step use small amount of 90% alcohol was used as binding solution to mix the formula, and then the formula was granulated through 40 mesh sieve. Then the granules were poured into Super Mixer mix for 2 minutes; then the wet granules we...

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PUM

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Abstract

The present invention relates to a composition for prophylaxis or treatment of urinary system infection, comprising a matrix metalloproteinase inhibitor. The present invention also relates to a method for prophylaxis or treatment of urinary system infection, comprising administering to a patient in need of such treatment an effective amount of composition comprising a matrix metalloproteinase inhibitor.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation-In-Part of U.S. patent application Ser. No. 11 / 422,924 filed on Jun. 6, 2006, now pending, and is hereby incorporated by reference in its entirety. Although incorporated by reference in its entirety, no arguments or disclaimers made in the parent application apply to this divisional application. Any disclaimer that may have occurred during the prosecution of the above-referenced application(s) is hereby expressly rescinded. Consequently, the Patent Office is asked to review the new set of claims in view of all of the prior arts of record and any search that the Office deems appropriate.FIELD OF THE INVENTION[0002]The present invention relates to a composition and a method for prophylaxis or treatment of urinary system infection.BACKGROUND OF THE INVENTIONUrinary System Infection[0003]Urinary System Infection, in particular urinary tract infection, may be defined as the presence of microorganisms in the u...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/254A61K36/45A61K36/752A61K36/31A61K36/73A61K36/87
CPCA61K31/00A61P13/00A61P13/02A61P31/04A61P43/00Y02A50/30
Inventor LIN, CHIH-HSIUNG
Owner LIN CHIH HSIUNG
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