Identification of Compounds Modifying A Cellular Response

US20090239755A1Inactive Publication Date: 2009-09-242CUREX
9 Cites 12 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
2CUREX
Publication Date
2009-09-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.
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Description

[0001] All patent and non-patent references cited in the application are hereby incorporated by reference in their entirety.FIELD OF INVENTION

[0002] The present invention relates to a method and tools for extracting information relating to an influence, for example on intracellular molecule(s), in particular an influence caused by contacting a cellular molecule with a substance, which has been released from a solid support to which a cell expressing the cellular component is attached. In particular the method related to a solid support that allow chemical synthesis of individual substances on beads of the solid support

[0003] The method of the invention may be used as a very efficient procedure for testing or discovering the influence of a library of substances on a physiological process, for example in connection with screening for new drugs, testing of substances for toxicity, identifying drug targets for known or novel drugs. Other valuable uses of the method and technology of the in...

Claims

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