Closure device and methods and systems for using same

Abstract

Embodiments of the present disclosure are directed to apical closure systems, devices, and methods and systems for use thereof, for closing surgical openings or defects in the wall of the heart.

Description

FIELD OF THE DISCLOSURE[0001]Embodiments of the present disclosure are directed to closure devices, more particularly, apical closure devices and methods and systems for use thereof, for closing surgical openings in the wall of the heart (for example).BACKGROUND OF THE DISCLOSURE[0002]Cardiovascular disease or cardiovascular diseases refers to the class of diseases that involve the heart or blood vessels (arteries and veins). This class of disease thus refers to any disease that affects the cardiovascular system any may include atherosclerosis (arterial disease), coronary artery disease, valvular heart disease, ischemic heart disease (IHD), or myocardial ischaemia. These diseases are characterized by reduced blood supply to the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). Depending on the symptoms and risk, treatment may be with medication, percutaneous coronary intervention (angioplasty) or conventional open-heart surgery.[0003]Be...

AI Technical Summary

Benefits of technology

[0043]According to some embodiments, a ventricle closure is provided having a support structure that is collapsible to a delivery state for implantation via an access opening in a ventricle wall, and self-expandable to a deployed or operative state upon implantation. The support structure may comprise a first portion for positioning or fitting in the access opening and/or a flange portion for being arranged substantially flat against the ventricle wall to prevent migration of the closure device in at least one direction. The flange portion may be for a distal portion of the ventricle closure fitting inside the ventricle and/or for a proximal portion of the ventricle closure fitting externally of the ventricle. Use of a flange portion fitting substantially flat against the ventricle wall can provide a low profile that does not project substantially with respect to the surface of the ventricle wall. If used inside the ventricle, the low profile is advantageous in reducing any risk of damage to internal heart tissue, and reducing possible interference to blood flow within the ventricle. If used outside the ventricle, the low profile is advantageous in reducing any risk of damage to the body surrounding the heart, for example, pericardium tissue. The ventricle closure may further comprise a cover component covering at least partially the outer surface of the support structure.

[0044]According to some embodiments, a ventricle closure is provided having a support structure that is collapsible to a delivery state for implantation via an access opening in a ventricle wall, and self-expandable to a deployed or operative state upon implantation. The support structure may comprise a first portion for positioning or fitting in the access opening and/or an anchor portion configured for bearing against the ventricle wall to prevent migration of the closure in at least one direction following implantation. The support structure may be configured not to project substantially from the exterior surface of the ventricle wall (e.g., from between 0 mm to about 2 mm, and in some embodiments, between about 0.001 mm and

Problems solved by technology

In some cases, in addition, the valve malfunctioning may affect more than one heart valve at the same time.

Additionally, these approaches require arrest of the patient's heart.

These techniques are thus extremely invasive and are accompanied risk of death or serious complications, depending on the comorbidities and age of the patient.

Older patients, as well as more fragile ones, are sometimes ineligible for surgery because of elevated risks.

Specifically, if the replacement valve is not placed in the proper position relative to the implantation site, it can affect the safety and efficacy of the valve.

For example, in an aortic valve replacement, if the replacement valve is placed too high, it can lead to valve regurgitation, instability, coronary occlusion.

If the valve is placed too low, it can also lead to regurgitation, to AV/block and interference with the mitral valve.

Safely closing a surgical opening of the f

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