Treatment of macrophage-related disorders

a macrophage and disorder technology, applied in the field of treatment of macrophage-related disorders, can solve the problems of inflammation that can dismantle tissues to the point of inflicting serious injury
US20120134929A1Inactive Publication Date: 2012-05-31RGT UNIV OF CALIFORNIA +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
RGT UNIV OF CALIFORNIA
Publication Date
2012-05-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a method of treating a macrophage related disease comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The present invention also provides a method of modulating macrophage accumulation or activation comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The oxidative agent can be chlorite or a chlorite containing compound.
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Description

[0001] This application claims benefit under 35 U.S.C. §119(e) to Provisional Application Nos. U.S. 61 / 231,989, filed Aug. 6, 2009, U.S. 61 / 232,678, filed Aug. 10, 2009, and U.S. 61 / 238,609, filed Aug. 31, 2009, each of which is herein incorporated by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] Macrophages are white blood cells produced by the division of monocytes. Monocytes and macrophages are phagocytes, and play a role in innate immunity (non-specific immune defenses) as well as helping to initiate adaptive immunity (specific defense mechanisms). These cells phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells. When activated by pathogens or by other mechanisms, macrophages stimulate and recruit lymphocytes and other immune cells to respond to the insult.

[0003] Although macrophages play a vital role in host immune defenses, activated macrophages are also involved in the progression of a number of diseases and dis...

Claims

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