Transgenic animals with customizable traits

a technology of transgenic animals and customizable traits, applied in the field of genetic modification of animals, can solve the problems of increasing or reducing their activity, and carotene dyes have never been naturally found in animals
US20130212722A1Inactive Publication Date: 2013-08-15AGGENETICS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
AGGENETICS
Publication Date
2013-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which it was applied.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the priority benefit of U.S. Provisional Application Ser. No. 61 / 598,987, filed Feb. 15, 2012, which is incorporated herein by reference in its entirety.

[0002] The Sequence Listing for this application is labeled SeqList-15Feb13_ST25.txt which was created on Feb. 15, 2013 and is 66 KB. The entire content of the sequence listing is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0003] This invention relates to genetic modification of animals in order to effect controlled changes in specified traits such as, for example, changes in skin and / or fur pigmentation.BACKGROUND OF THE INVENTION

[0004] The only pigment synthesized in most animal species, and the only pigment at all in mammalian species, is melanin. There are two classes of melanin pheomelanin, which produces a blond or red color, and eumelanin, which produces a dark brown or black color. Both classes of melanin are synthesized from tyrosin...

Claims

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