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Spectroscopic analysis

a spectroscopic analyzer and spectroscopic technology, applied in the field of spectroscopic analyzers, can solve the problems of difficult discrimination between different substances and often inaccurate analysis of analysers, and achieve the effect of removing the dark curren

Inactive Publication Date: 2013-10-10
KLEIN MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is related to a method and apparatus for identifying or verifying a liquid sample, such as a drug sample, using electromagnetic radiation. The method involves emitting electromagnetic radiation at the sample and detecting the affected radiation. A processor then analyzes the detected radiation to identify or verify the sample. The method uses multiple wavelengths of electromagnetic radiation that are selected based on their ability to improve the identification of drugs in the liquid carrier. The apparatus includes an electromagnetic radiation source, a sample detector, and a processor for analyzing the detected radiation. The method and apparatus can provide accurate and reliable identification or verification of liquid samples.

Problems solved by technology

However, such analysers often provide inaccurate analysis.
Accurately discriminating between different substances can be difficult.

Method used

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first embodiment

[0216]One embodiment of the invention will now be described in detail by way of example. This should not be considered limiting but illustrative. The embodiment is described in relation to an apparatus for providing verification or identification of water or other liquid based drugs from e.g. a set of 15 drugs set out in the table below. While in this embodiment the sample is referred to as a drug, more generally the embodiment could be applied to any other sample type.

[0217]Six wavelengths of electromagnetic radiation are chosen for this example, six being greater than log2n of 30. The wavelengths are chosen in the analysis range and are based on the spectral characteristics of water, being the base liquid, falling in that range. The spectrum of a water based drug (or other liquid based drug or aqueous solution) will be heavily dominated by the base liquid spectrum. For example referring to FIG. 5, the spectrum (dotted line) of drug W (gelofusine succinated gelatine solution 4%) is...

second embodiment

[0376]One possible embodiment of the invention will now be described in detail by way of example. This should not be considered limiting but illustrative. The embodiment is described in relation to an apparatus for providing verification or identification of water based drugs from e.g. a set of 30 drugs.

[0377]Six wavelengths of electromagnetic radiation are chosen for this example, six being greater than log2n of 30. The wavelengths are chosen in the analysis range and are based on the spectral characteristics of water, being the base liquid, falling in that range. The spectrum of a water based drug (or other liquid based drug or aqueous solution) will be heavily dominated by the base liquid spectrum. For example referring to FIG. 5, the spectrum (dotted line) of drug W (gelofusine succinated gelatine solution 4%) is very similar to the spectrum of water (solid line). This is because the spectrum of water dominates. However, the differences in transmission coefficient between differ...

third embodiment

[0418]FIG. 12 shows an alternative embodiment of the apparatus 10. In this embodiment rather than using a carousel 50 or single package laser as per FIGS. 21A, 21B, the six lasers 51a-51f forming the source 11 are arranged to emit their electromagnetic radiation beam 22 towards a diffraction grating 120 of the reflection type. Each laser 51a-51f is operable to emit a tuned or tunable wavelength of a collimated electromagnetic beam 22 towards the diffraction grating. The angle of incidence X on the grating surface for each laser 51a-51f is chosen that their first order diffracted beam emerges at the same angle Y thereby producing a common optical path 14a for each laser. The controller 12 activates each laser 51a-51f sequentially to emit a beam of a single wavelength towards the sample. Alternatively, multiple lasers 51a-51f could be operated at once such that an electromagnetic beam 22 comprising multiple wavelength components could be emitted towards the sample 16. A separate grati...

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Abstract

An analyser and related methods for characterising a sample. The analyser includes an integrated laser for emitting electromagnetic radiation in at least one beam at a sample. The electromagnetic radiation can include at least two different wavelengths. A sample detector detects affected electromagnetic radiation resulting from the emitted electromagnetic radiation affected by the sample and provides output representing the detected affected radiation. The analyser also includes a processor for characterising the sample from the detector output representing the detected affected electromagnetic radiation.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a spectroscopic analyser, such as a spectrophotometer, for verifying and / or identifying or otherwise analysing drugs, blood or other substances.BACKGROUND OF THE INVENTION[0002]Spectroscopy, for example through the use of a spectroscopic analyser such as a spectrophotometer, can be used to analyse substances. For example, by directing incident radiation towards a sample, and analysing the spectral nature of the affected radiation, it can be possible to gain an indication of the nature of the sample.[0003]However, such analysers often provide inaccurate analysis. Accurately discriminating between different substances can be difficult.SUMMARY OF INVENTION[0004]It is an object of the present invention to provide an analyser and / or method for verifying or identifying or otherwise characterising a drug or other substances using spectroscopy.[0005]The embodiments described in the present specification are directed towards drug c...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N21/27G01N21/31G01N33/49
CPCG01J3/10G01J3/42G01J2003/1286G01N2021/3595G01N2201/0691G01J3/28G01N21/84G01N21/3577G01J3/427G01N21/359G01N2201/0612
Inventor SMITH, BRYAN JAMESKROUSE, DONAL PAULSIMPKIN, RAYMOND ANDREW
Owner KLEIN MEDICAL
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