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Bone Cement With Adapted Mechanical Properties

a technology of mechanical properties and bone cement, applied in the field of bone cement with adapted mechanical properties, can solve problems such as mismatch in stiffness, and achieve the effect of reducing stiffness and reducing stiffness

Inactive Publication Date: 2014-04-10
DEPUY SYNTHES PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The modified bone cement exhibits reduced stiffness by 50% or more, increased handling time for safer surgical procedures, and lower polymerization temperatures, minimizing tissue necrosis and toxicity, thus addressing the mechanical mismatch and procedural challenges of traditional bone cements.

Problems solved by technology

This mismatch in stiffness is generally perceived as favoring the subsequent fracturing of the vertebral bodies that are adjacent to the augmented vertebral body.

Method used

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  • Bone Cement With Adapted Mechanical Properties

Examples

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Effect test

example

[0023]The following example was carried out using commercial PMMA cement Vertecem. Vertecem is a fast setting, radiopaque acrylic bone cement for use in percutaneous vertebroplasty. The fluid phase is composed of 97.6% methyl-methacrylate (MMA), 2.4% N,N-dimethyl-p-toluidine as activator and very small quantities (20 ppm) of hydroquinones as stabilizer. The polymer powder is composed of 64.4% PMMA, 0.6% benzoyl peroxide which initiates the polymerization, 25% barium sulfate as radiopaque agent and 10% hydroxyapatite.

[0024]The fluid MMA monomer phase was partly substituted by NMP organic solvent by different amounts. NMP is totally miscible with the MMA monomer fluid. The amounts of MMA, and NMP, and PMMA used in the different compositions are listed in Table 1.

TABLE 1SampleMMA / NMP / PMMAStiffness / Yield strength / Namemlmlpowder / gMPa AverageMPa Average 0%1002123847820%822118388630%73217525250%55214563760%462132024

[0025]The MMA monomer and NMP was premixed to form a fluid mixture. Subsequ...

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Abstract

A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

Description

RELATED APPLICATION[0001]This patent application is a divisional application of U.S. application Ser. No. 12 / 529,562, filed Sep. 2, 2009, which is a U.S. National Stage filing of International Patent Application Serial No. PCT / US2008 / 002811, filed Feb. 29, 2008, which claims benefit to U.S. Provisional Patent Application Ser. No. 60 / 904,673, filed Mar. 2, 2007, and to U.S. Provisional Patent Application Ser. No. 60 / 967,052, filed Aug. 31, 2007. The applications are incorporated herein by reference in their entireties.BACKGROUND[0002]Vertebral compression fractures in osteoporotic patients are typically treated by a surgical procedure known as vertebroplasty. In this procedure the fractured vertebral body is augmented with a bone cement. The bone cement polymerizes and hardens upon injection into the vertebral body and stabilizes the fracture. Pain relief for the patient is usually immediate and vertebroplasty procedures are characterized by a high rate of success.[0003]Typically, bo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L24/00
CPCA61L24/0036A61L24/0084A61L24/0094A61L24/06A61L2430/02C08L33/12A61L24/04
Inventor GRUSKIN, ELLIOTTBOGER, ANDREASMONTALI, ANDREAWHEELER, KURTIS
Owner DEPUY SYNTHES PROD INC
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