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Composition for Intravascular Delivery of Therapeutic Composition

a technology of therapeutic composition and composition, which is applied in the direction of dilators, biocide, catheters, etc., can solve the problems of undesirable preparation and unsatisfactory polymeric coatings

Inactive Publication Date: 2015-06-18
SURMODICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition effectively delivers the therapeutic agent deep into tissues, enhancing penetration and retention, thereby improving the efficacy of drug delivery for intravascular applications.

Problems solved by technology

Such preparations are generally undesirable because the drug can be easily removed from the surface during insertion.
However, these polymeric coatings may not be ideal for applications involving the transient insertion of a medical device to a target tissue in the body.

Method used

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  • Composition for Intravascular Delivery of Therapeutic Composition
  • Composition for Intravascular Delivery of Therapeutic Composition
  • Composition for Intravascular Delivery of Therapeutic Composition

Examples

Experimental program
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Effect test

example

The Present Pharmaceutical Composition Increased Paclitaxel Penetration Into and Through Arterial Tissue

[0107]Certain embodiments of the present pharmaceutical composition increased transfer of paclitaxel from a balloon catheter into and through arterial tissue in an ex-vivo model.

Preparing a Double Wall Catheter Containing the Present Therapeutic Composition

[0108]Holes were poked in thin walled silicone tubing with a piece of 0.014 inch diameter nitinol wire. The tubing was then washed extensively and repeatedly—a sonication, washing with hot water and an alkaline detergent, followed by two more sonications. The tubing was then coated with first coat of a scissile coating. It was immersed in a 2 mg / ml solution of photo-polyvinylpyrrolidone (as described in U.S. Pat. No. 6,007,833) in deionized water, bubbles were removed, and it was subjected to UV cure (Dymax 2000-EC Series UV Floodlamp with a 400 Watt metal halide bulb, approximately 20 cm from light source, illuminated for four ...

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Abstract

The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims benefit of U.S. Provisional Application No. 61 / 428,397, filed Dec. 30, 2010, which application is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.BACKGROUND OF THE INVENTION[0003]The release of drugs from an implanted medical device has been shown to be beneficial for the function of devices and the treatment of various medical conditions. For example, delivery of a drug from the device surface can prevent cellular responses initiated by the presence ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/22A61M25/10A61M25/00A61K31/337A61F2/958
CPCA61K47/22A61K31/337A61M2025/1088A61M25/0026A61M2025/105A61M25/1011A61K9/0019A61K31/436A61M25/0009A61M25/0045A61M25/1029A61M2025/1004A61M2025/1013A61L29/16A61L2300/416
Inventor CHAPPA, RALPH A.
Owner SURMODICS INC