Carbon nanotube compositions and methods of use thereof

a technology of carbon nanotubes and compositions, applied in the field of carbon nanotube compositions, can solve the problems of limited malaria and hiv, and many other infectious diseases involving intracellular pathogens, and achieve the limitation of the development of deadly diseases vaccines, and the development of many other infectious diseases
US20160213761A1Inactive Publication Date: 2016-07-28YALE UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YALE UNIV
Publication Date
2016-07-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and / or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of pending application Ser. No. 13 / 842,782, filed Mar. 15, 2013, which is a continuation in part of U.S. Ser. No. 12 / 933,223, now U.S. Pat. No. 8,658,174, filed Sep. 17, 2010, which is the National Stage of International Application No. PCT / US09 / 37727 filed Mar. 19, 2009, which claims priority to and benefit of U.S. Provisional Patent Application No. 61 / 037,798, filed on Mar. 19, 2008, the contents of which are incorporated by reference in their entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] This invention was made with government support awarded by the National Science Foundation under Career Award Number 0747577 to Tarek M. Fahmy. The United States government has certain rights in this invention.FIELD OF THE INVENTION

[0003] The present disclosure generally relates to the field of carbon nanotube compositions and methods for making and using these compositions.BACKGROUND OF...

Claims

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