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Method for the Treatment of Neuropathies and/or Neuropathic Pain

a neuropathology and neuropathy technology, applied in the field of composition, can solve problems such as pathological neuropathies, achieve the effects of restoring the physiological activity of insulin itself, promoting and directing axonal growth, and improving the production of ng

Inactive Publication Date: 2018-08-30
KOLINPHARMA SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text discusses the effects of curcuminoids, which have the ability to prevent the formation of free radicals and help neutralize existing ones in the body. It also mentions the role of vitamin B6 in protecting nerve cells and reducing pain symptoms by promoting the production of serotonin. Overall, the patent aims to provide a technical approach to combating oxidative stress and its associated symptoms.

Problems solved by technology

Neuropathic pain is pathological in that it does not represent a useful and protective function for the organism; in fact, it is characterized by a process of amplification of the nociceptive messages that may be manifested both in the peripheral and in the central nervous system.

Method used

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  • Method for the Treatment of Neuropathies and/or Neuropathic Pain
  • Method for the Treatment of Neuropathies and/or Neuropathic Pain
  • Method for the Treatment of Neuropathies and/or Neuropathic Pain

Examples

Experimental program
Comparison scheme
Effect test

formulation example

1.08 g Tablet

[0069]

TABLE 1N-acetyl-carnitine400mgAlpha-lipoic acid300mgCurcuma longa dry extract150mgof which curcuma142.95mgVitamin C125mgVitamin E9mgVitamin B1 (thiamine)6.25mgVitamin B2 (riboflavin)6.25mgVitamin B6 (pyridoxine)2.38mgVitamin B12 (cyanocobalamin)6.25mg

[0070]The recommended dose is one or two tablets daily.

example 1

Evaluation of Anti-Inflammatory Activity and Quantification of Oxidative Stress

[0071]Rationale

[0072]The composition of the invention has, as pathological target, neuropathic pain from trauma or from an inflammatory effect. Neuropathic pain is a chronic condition caused by lesions or dysfunctions of the somatosensory nervous system. Damage to a peripheral nerve may cause amplification of the response, as a result of painful stimuli applied peripherally, at the level of the first synapse of the nociceptive pathway, causing neuronal hyperactivity at spinal cord level. The non-neuronal cells have a key role in the molecular mechanisms of neuropathic pain. In particular, as a result of damage of a peripheral nerve, alteration of the “blood-spinal cord barrier” (BSCB) may be observed, with consequent infiltration of macrophages and T-lymphocytes. These cells of the peripheral immune system, together with astrocytes and microglial cells, secrete pro-inflammatory cytokines and chemokines ca...

example 2

Study of the Anti-Free-Radical Synergy Between the Components of a Dietary Supplement in Cell Cultures of Human Monocytes (THP-1)

[0119]The purpose of the assay is to evaluate the antioxidant activity of the individual components of the dietary supplement Xinepa and the synergy between them, by measuring its capacity for neutralizing the reactive oxygen species (ROS) in a cell line of human monocytes (THP-1). To identify the non-cytotoxic concentrations of the product in question, a colorimetric assay (MTT assay) was used as a preliminary test.

[0120]Table 2 below shows the composition of the product used in the assay in question.

TABLE 2mg / doseSubstance(one tablet)Curcuma150.00Lipoic acid300.00Vitamin C125.00Vitamin E acetate9.00N-Acetyl-L-carnitine400.00Vitamin B16.25Vitamin B26.25Vitamin B66.25Vitamin B126.25

[0121]The individual components tested for investigating synergy are shown below:[0122]COMPONENT A: curcuma [0123]COMPONENT B: lipoic acid, vitamin C, vitamin E acetate[0124]COM...

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Abstract

A method of treating a subject having neuropathies and / or neuropathic pain, that includes administering a pharmaceutical composition or dietary supplement having, as the active ingredients, Curcuma longa extract, acetyl ester of L-carnitine and alpha-lipoic acidA is described.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is a continuation of U.S. Ser. No. 15 / 503,080 filed Feb. 10, 2017, now allowed, which is a national stage application filed under 35 U.S.C. § 371 of international application PCT / IB2015 / 056266, filed under the authority of the Patent Cooperation Treaty on Aug. 18, 2015, published; which claims the benefit of Patent Application No. TO2014A000670, filed on Aug. 19, 2014. The entire disclosures of all the aforementioned applications are expressly incorporated herein by reference for all purposes.FIELD OF INVENTION[0002]The invention relates to a composition to be used in the field of the treatment of neuropathies and neuropathic pain.[0003]In particular, the invention relates to a mixture of compounds capable of exerting both a neuroprotective action, mediated by an anti-inflammatory and antioxidant activity, and a neurotrophic and energizing action able to supply nutrients to the fibres and, by increasing the energy metabolism, to rest...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/385A61K31/714A61K31/675A61K36/9066A61K31/12A61K31/221A61K9/00A61K31/375A61K31/355A61K31/51A61K31/525
CPCA61K31/714A61K31/675A61K31/385A61K36/9066A61K31/12A61K31/221A61K9/0053A61K31/375A61K31/355A61K31/51A61K31/525A61K31/205A61P25/00A61P25/02A61P29/00A61K2300/00
Inventor BIJNO, DOMENICODI VINCENZO, CARMINELUSENTI, EMANUELEMARTINA, ALBERTOPETRELLI, RITAPAOLA
Owner KOLINPHARMA SPA