Gamma-hydroxybutyrate compositions and their use for the treatment of disorders

a technology of gamma-hydroxybutyrate and compositions, which is applied in the direction of anhydride/acid/halide active ingredients, medical preparations, nervous disorders, etc., can solve the problems of increasing the sodium intake of patients, and achieve the effect of reducing the level of growth hormone and increasing the intracranial pressur
US20200113853A1Inactive Publication Date: 2020-04-16JAZZ PHARMA IRELAND LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
JAZZ PHARMA IRELAND LTD
Publication Date
2020-04-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
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Description

CROSS REFERENCE

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 62 / 472,232, filed Mar. 17, 2017, the content of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0002] Provided herein are pharmaceutical compositions and formulations comprising salts of gamma-hydroxybutyrate (GHB). In one embodiment, the salts encompass more than one type of cation. Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of the treatment of disorders including fibromyalgia and sleep disorders. Also described herein is that such pharmaceutical compositions and formulations are for treating diseases or disorders including fibromyalgia and sleep disorders. Such sleep disorders include apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.BACKGROUND OF THE INVENTION

[0003] Sodium oxybate (Na⋅GHB), comm...

Claims

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