Composition comprising aqueous medium with reduced size water clusters to improve bioavailability of the aqueous medium and methods for making and using the compositions

Abstract

The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H₂O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H₂O substance to less than 300 nanometers.

Description

BACKGROUND OF THE INVENTION[0001]The common 2D view of H2O is illustrated in FIG. 1 where two (2) hydrogen atoms 401, 404 are chemically bonded to one (1) oxygen atom 402 at a 106 angle to makes make a polar molecule with an electronic size (dashed line) of 0.28 by 0.32 nanometers. H2O is known to ionize to hydronium cations and hydroxonium anions (OH−). The hydronium ion is often given the empirical molecular formula H3O+ and depicted in 2D as an oxygen atom 400 bonded to three hydrogen atoms 401, 402, and 403 with the dashed line 404 defining its 2D electronic size (see FIG. 4). The hydroxonium ion (traditionally called hydroxide ion with molecular formula OH−) is depicted in FIG. 3 as an oxygen atom 301 and a hydrogen atom 302.[0002]Each H2O molecule can form up to four hydrogen bonds in liquid water. FIG. 2 illustrates a hydrogen bond between two (2) water molecules. Oxygen atom 202 is hydrogen bonded to water molecule hydrogen atom 201. Most models for intermolecular water H-bo...

AI Technical Summary

Benefits of technology

[0049]In some embodiments, the present invention is a process for reducing water cluster sizes in an aqueous composition containing a non-H2O substance in order to improve bioavailability of the aqueous composition, the process comprising the steps of: choosing an amount of non-H2O substance to be added to a large volume of ultrapure water; blending all of the non-H2O substance in a small volume of the ultrapure water to make a small volume concentrate of the non-H2O substance in the ultrapure water; wherein the small volume concentrate of the non-H2O substance blended with the ultrapure water is a percent of the large volume of the ultrapure water that has been chosen, the percent may be selected from the group consisting of a 0.01 to 0.05 percent, a 0.05 to 0.1 percentage, a 0.1 to 0.2 percentage, a 0.2 to 0.3 percent, a 0.3 to 0.4 percent, a 0.4 to 0.5 percent, a 0.5 to 0.6 percent, a 0.6 to 0.7 percent, a 0.7 to 0.8 percent, a 0.8 to 0.9 percent, a 0.9 to 1.0 percent, a 1.0 to 2.0 percent, a 2.0 to 3.0 percent, a 3.0 to 4.0 percent, a 4.0 to 5.0 percent, a 5.0 to 10.0 percent, a 10.0 to 20.0 percent, and a combination thereof; filtering optionally, the small volume concentrate of the non-H2O substance in the ultrapure water using a clean filter to remove micron-sized particulates from the small volume concentrate, wherein the minimum particle sizes removed by the clean filter may be selected from the group consisting of about 1 to 2 microns, 2.5 microns, 3 microns, 4 to 7 microns, 6 microns, 8-10 microns, 11 microns, and 12-25 microns, and a combination thereof; recirculating the large volume of the ultrapure water in a mixing tank and slowly adding the small volume concentrate of the non-H2O substance in the ultrapure water to the mixing tank to form a blended aqueous composition containing the non-H2O substance in an aqueous medium; wherein the large volume amount of the ultrapure water may be selected from the group consisting of about 10 to 20 gallons, about 20 to 50 gallons, about 50 to 100 gallons, about 100-300 gallons, about 300 to 600 gallons, about 600 gallons to about 1000 gallons, about 1000 gallons to about 2500 gallons, and a combination thereof, and wherein the adding of the small volume concentrate volume of the non-H2O substance in the ultrapure water to the mixing tank to form a blended aqueous composition containing the non-H2O substance in the aqueous medium may be accomplished over a time period selected from th...

Problems solved by technology

The obvious limitation of the Keutsch study is probably that he studied only UPW which is never the state of biological water.

Unfortunately, regarding aqueous solutions in the liquid state—the structural information that can be obtained from diffraction studies on liquid species is limited because of the continual translational and rotational movement of the molecules (taken from Plumridge & Waigh, 2002).

(3) A polar residue that is geometrically incompatible with structured water may be transmitted by water molecules to neighboring groups and lead to a disruption of hydrophobic bonding.

However, when an additional non-water substance is present or water is confined, then the hydrogen bonding should no longer be randomized and mere...

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