Deuterated tetrapeptides that target mitochondria

a technology of mitochondria and deuterated tetrapeptides, which is applied in the direction of peptides, drug compositions, peptides/protein ingredients, etc., can solve the problems of poor absorption, distribution, metabolism and/or excretion (adme) properties, and many current medicines suffer
US20200361987A1Inactive Publication Date: 2020-11-19STEALTH BIOTHERAPEUTICS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
STEALTH BIOTHERAPEUTICS INC
Publication Date
2020-11-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are deuterated analogs of SBT-20 and elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.
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Description

RELATED APPLICATION

[0001] This application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 62 / 586,336, filed Nov. 15, 2017.BACKGROUND OF THE INVENTION

[0002] Many current medicines suffer from poor absorption, distribution, metabolism and / or excretion (ADME) properties that prevent their wider use or limit their use in certain indications. Poor ADME properties are also a major reason for the failure of many drug candidates in clinical trials. While formulation technologies and prodrug strategies can be employed in some cases to improve or alter certain ADME properties, these approaches often fail to address the underlying ADME problems that exist for many drugs and drug candidates. One such problem is rapid metabolism that causes a number of drugs, which otherwise would be highly effective in treating a disease, to be cleared too rapidly from the body. A possible solution to rapid drug clearance is frequent or high dosing to attain a sufficiently high pla...

Claims

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