Lipid nanoparticles as oral vehicles of immunotherapy

a technology of lipid nanoparticles and immunotherapy, which is applied in the direction of drug compositions, peptide/protein ingredients, metabolic disorders, etc., can solve the problems of t1d autoreactivity development that is much longer, remains quite elusive, and is not easy to be detected and treated, and achieves the potential for local and systemic pathophysiologic effects, low bioavailability, and low bioavailability
US20220339116A1Pending Publication Date: 2022-10-27THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Publication Date
2022-10-27

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Abstract

Lipid nanoparticle compositions for use in immunomodulation and treatment of autoimmune and related diseases such as Type 1 Diabetes are provided along with methods for using same.
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Description

REFERENCE TO RELATED APPLICATIONS

[0001] This application is a § 371 U.S. National Entry Application of PCT / US2020 / 026574, filed Apr. 3, 2020, which claims the benefit of U.S. Provisional Patent Application No. 62 / 828,743, filed on Apr. 3, 2019 and U.S. Provisional Patent Application No. 62 / 858,775, filed on Jun. 7, 2019, each of which are hereby incorporated by reference for all purposes as if fully set forth herein.STATEMENT OF GOVERNMENTAL INTEREST

[0002] This invention was made with government support under grant HL127355 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND OF THE INVENTION

[0003] Autoimmune diseases are pathologies caused by the erroneous attack of a patient immune system against an organ or tissues of the own body. Autoimmune diseases are often treated with immunosuppressants that weaken the entire immune system, leaving patients vulnerable to infection. An ideal autoimmune therapy establishes immune tolerance t...

Claims

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