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36 results about "Histamine H4 receptor" patented technology
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The histamine H₄ receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
Indoles and benzoimidazoles as histamine H4 receptor modulators
Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor
Owner:JANSSEN PHARMA NV
2-Aminopyrimidine modulators of the histamine H4 receptor
2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor
Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Thieno-and furo-pyrimidine modulators of the histamine H4 receptor
Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Owner:JANSSEN PHARMA NV
Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor
Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Use of Histamine H4 antagonist for the treatment of post-operative adhesions
The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering a histamine H4 receptor antagonist, systemically, directly to tissue surfaces in the body cavity, or both, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.
Owner:JANSSEN PHARMA NV
Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor
Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Benzofuro- and benzothienopyrimidine modulators of the histamine H4 receptor
Benzofuro- and benzothienopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor
InactiveUS8841287B2Maintain good propertiesLower Level RequirementsBiocideSenses disorderDiseaseHistamine H1 receptor
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Use of a histamine H4 antagonist for the treatment of post-operative adhesions
The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering a histamine H4 receptor antagonist, systemically, directly to tissue surfaces in the body cavity, or both, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.
Owner:JANSSEN PHARMA NV
Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Owner:JANSSEN PHARMA NV
Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
Owner:JANSSEN PHARMA NV
Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor
InactiveUS20110092474A1Maintain good propertiesLower Level RequirementsBiocideSenses disorderAutoimmune diseasePyridine
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Analyzing Histamine H4 Receptor-Mediated Effects In Whole Blood
Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.
Owner:KARLSSON LARS +3
4-aminopyrimidine derivatives as histamine H4 receptor antagonists
4-Amino-pyrimidine derivatives of Formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.
Owner:PALAU PHARMA
Use of histamine H4 antagonist for the treatment of post-operative adhesions
Owner:JANSSEN PHARMA NV
Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders
InactiveUS20120039913A1Decrease constitutive levelAntibacterial agentsOrganic active ingredientsDiseaseFhit gene
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
2-aminopyrimidine derivatives as modulators of the histamine h4 receptor activity
2-Aminopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as modulators of the H4 receptor.
Owner:PALAU PHARMA SA
Substituted heterocylic compounds
Owner:INCYTE CORP
Substituted heterocyclic compounds
The present invention relates to substituted heterocyclic compounds of Formula I:or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors / antagonists useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
Owner:INCYTE CORP
Substituted Heterocyclic Compounds
The present invention relates to substituted heterocyclic compounds of Formula I:or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors / antagonists useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
Owner:INCYTE
Indoles and benzoimidazoles as modulators of the histamine H4 receptor
Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Owner:JANSSEN PHARMA NV
Substituted heterocyclic compounds
The present invention relates to substituted heterocyclic compounds of Formula I or XI:or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
Owner:INCYTE CORP
4-aminopyrimidine derivatives as histamine H4 receptor antagonists
Owner:PALAU PHARMA SA
Benzimidazole derivatives as dual histamine h1 and histamine h4 receptor ligands
PendingUS20220281839A1Good treatment effectImprove securityOrganic active ingredientsAntipyreticBenzimidazole derivativePerylene derivatives
The present application concerns novel benzimidazole enantiomeric derivatives, their process of preparation and their therapeutical uses as dual H1 and H4 receptor ligands.
Owner:BIOPROJET
Process for the Preparation of Benzoimidazol-2-yl Pyrimidine Derivatives
ActiveUS20140357865A1Modulating activity of receptorOrganic chemistry methodsHistamine hReceptor modulator
The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
Owner:JANSSEN PHARMA NV
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