The invention discloses an eight-channel coronary artery disease diagnostic instrument which comprises a sound collecting module used for collecting human body organ audio signals, an ASIC digital signal processing module used for carrying out audio frequency spectrum analysis, a wireless signal receiving module used for carrying out wireless reception, a cloud end processing module used for sharing cloud ends, an image processing module used for processing images and a display module used for observation by a doctor, wherein the sound collecting module comprises a sound sensor, a differentialprocessor module, a filtering module, a signal amplifying module and an ADC module; the filtering module comprises a high-pass filter, a low-pass filter, a low-frequency band trap and a high-frequency band trap. By the adoption of the eight-channel coronary artery disease diagnostic instrument, abnormal conditions and parts of coronary artery of a heart can be shown, ignoring of the abnormal conditions when a doctor detects the coronary artery of the heart can be avoided, a patient can conveniently know a physical condition of oneself in time, so that a rapid treatment is achieved, a diagnosis rate of cardiovascular diseases is effectively improved, a diagnosis technical level of the doctor is improved, thereby helping the doctor to diagnose difficult and complicated diseases.