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Oral disintegration tablet of ectractive from ginkgo leaf and preparation method

A technology of extract and ginkgo biloba, which is applied in the field of pharmaceutical preparations and preparations, can solve problems such as complex processes and large losses, and achieve the effects of simple preparation processes, reduced contact, and reduced production costs

Inactive Publication Date: 2007-09-12
浙江康恩贝药品研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The currently used drug coating technology is relatively complicated. Fluidized bed coating requires the use of large-scale equipment such as a fluidized bed, and not every unit is qualified; the disadvantage of microencapsulated coating is that the drug is microencapsulated. The loss in the process is relatively large, and the encapsulation rate of the drug must be measured, and the drug should be dosed according to the drug content.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Orally disintegrating tablet containing 80 mg of Ginkgo biloba extract

[0016] Referring to Table 1, the unit composition and percentage composition of the tablet of the present invention are provided

[0017] Element

Unit Composition

percentage (%)

Ginkgo biloba extract

80mg

16.7

Ethyl cellulose

40mg

8.3

Dilute ethanol

8ml

------

lactose

240mg

50.0

aspartame

2.4mg

0.5

sodium bicarbonate

9mg

1.9

citric acid

10.2mg

2.1

Croscarmellose Sodium

96mg

20.0

Magnesium stearate

2.4mg

0.5

total

480mg

100.0

[0018] Preparation method:

[0019] (1) Dissolve the prescribed amount of ethyl cellulose in dilute ethanol to obtain a coating solution.

[0020] (2) Weighing the prescribed amount of Ginkgo biloba extract into the coating solution, stirring, and ultrasonically dispe...

Embodiment 2

[0029] Embodiment 2, orally disintegrating tablet containing 80 mg of Ginkgo biloba extract

[0030] Referring to Table 2, the unit composition and percentage composition of the tablet of the present invention are provided

[0031] Element

Unit Composition

percentage (%)

Ginkgo biloba extract

80mg

16.7

Methylcellulose

40mg

8.3

Dilute ethanol

8ml

---

Mannitol

100mg

20.8

microcrystalline cellulose

140mg

24.2

stevioside

2.8mg

0.6

Menthol

2mg

0.4

citric acid

13mg

2.7

sodium bicarbonate

11mg

2.3

Crospovidone

86.4mg

18.0

Magnesium stearate

4.8mg

1.0

total

480mg

100.0

[0032] Preparation method is the same as embodiment 1

[0033] Results: The average disintegration time of the tablet compressed by this method in the oral cavity is less than 20 seconds...

Embodiment 3

[0034] Embodiment 3, orally disintegrating tablet containing 80 mg of Ginkgo biloba extract

[0035] See Table 3 for the unit composition and percentage composition of the tablet

[0036] Element

Unit Composition

percentage (%)

Ginkgo biloba extract

80mg

20.0

[0037] Methylcellulose

20mg

5.0

Ethyl cellulose

20mg

5.0

Dilute ethanol

10ml

---

Mannitol

76mg

19.0

microcrystalline cellulose

100mg

25.0

sucrose

1.4mg

0.4

Menthol

1mg

0.2

citric acid

15mg

3.8

sodium bicarbonate

13mg

3.2

Sodium carboxymethyl starch

68mg

14.25

Magnesium stearate

5.6mg

1.4

total

400mg

100.0

[0038] Prepare with the method of embodiment 1.

[0039] Results: The average disintegration time of the tablets compressed by this method in the oral cavity...

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PUM

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Abstract

A Chinese medicine in the form of oral disintegrating tablet is prepared from gingko leaf through extracting, preparing coated particles and preparing oral disintegrating tablets. It features its agreeable taste.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method, in particular to ginkgo leaf extract and a preparation method thereof, in particular to ginkgo leaf extract orally disintegrating tablets and a preparation method thereof. Background technique [0002] Chinese patents 02134126.5 and 02116223.9 respectively describe the preparation of dispersible tablets and sustained-release tablets of Ginkgo biloba extract. They are not related to flavor problem, and Ginkgo biloba extract itself tastes extremely bitter. Chinese patent 00126538.5 describes the preparation of ginkgo biloba extract chewable tablets, all of which are flavored by adding sweeteners and flavoring agents. Excessive carbohydrate intake is its disadvantage. [0003] The currently used drug coating technology is relatively complicated. Fluidized bed coating requires the use of large-scale equipment such as a fluidized bed, and not every unit is qualified; the disad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K9/20A61K127/00
Inventor 夏亚君徐洪明王如伟
Owner 浙江康恩贝药品研究开发有限公司